Xiang J-W, Chen Z-G, Gong L, Xiao Y, Qing W-J, Wang L, Hu X-H, Huang Z-X, Qi R-L, Yang T-H, Arrigo A-P, Zhang L, Tang X-C, Huang S, Liu F-Y, Luo Z-W, Liu Y-F, Sun Q, Gigantelli J, Liu Y-Z, Li D W-C
Key Laboratory of Protein Chemistry and Developmental Biology of Educational Ministry of China, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081,. China.
Curr Mol Med. 2017;16(10):859-870. doi: 10.2174/1566524017666170109123238.
Sumoylation, a post-translational modification discovered over a decade ago, turns out to be a very important regulatory mechanism mediating multiple cellular processes. Recent studies from our laboratory and others also revealed that it plays a crucial role in regulating both differentiation and pathogenesis of the ocular lens. This review will summarize these progresses.
泛素样修饰（SUMO化）是十多年前发现的一种翻译后修饰，结果证明它是介导多种细胞过程的非常重要的调节机制。我们实验室和其他机构最近的研究还表明，它在调节晶状体的分化和发病机制中起着关键作用。本综述将总结这些进展。
