Behinaein S, Chettle D R, Fisher M, Manton W I, Marro L, Fleming D E B, Healey N, Inskip M, Arbuckle T E, McNeill F E
McMaster University, Hamilton, ON, Canada.
Physiol Meas. 2017 Mar;38(3):431-451. doi: 10.1088/1361-6579/aa57b9. Epub 2017 Jan 9.
To study the age and sex influence on bone and blood lead concentrations in a cohort of the general population living in Toronto.
A Cd K x-ray fluorescence (KXRF) measurement system was used from 2009 to 2011 in a study that measured the bone lead (Pb) concentration of 263 environmentally exposed individuals residing in Toronto, Ontario, Canada. Tibia (cortical bone) and calcaneus (trabecular bone) lead contents were measured in 134 males and 129 females between 1 and 82 years of age. Whole blood Pb concentration was measured by TIMS (thermal ionization mass spectrometer). Tibia (Ti) and calcaneus (Cal) Pb were examined versus the age of participants, taking into account uncertainties in bone Pb measurement values.
No significant sex differences were observed in any of the age categories. Participants older than 50 years of age demonstrated the highest concentrations of Pb in their blood, tibia, and calcaneus bones.
In most of the previous publications, uncertainty was not considered in the regression model of bone Pb and age. However, in this paper, we adjusted the bone Pb values for the uncertainty level. This had a significant influence in regression models of bone Pb and thus we recommend that uncertainty be considered in future studies.
研究年龄和性别对居住在多伦多的普通人群队列中骨铅和血铅浓度的影响。
在2009年至2011年的一项研究中，使用镉K X射线荧光（KXRF）测量系统，测量了加拿大安大略省多伦多市263名环境暴露个体的骨铅（Pb）浓度。在134名男性和129名年龄在1至82岁之间的女性中测量了胫骨（皮质骨）和跟骨（松质骨）的铅含量。通过热电离质谱仪（TIMS）测量全血铅浓度。考虑到骨铅测量值的不确定性，研究了胫骨（Ti）和跟骨（Cal）铅含量与参与者年龄的关系。
在任何年龄组中均未观察到明显的性别差异。50岁以上的参与者血铅、胫骨和跟骨中的铅浓度最高。
在大多数以前的出版物中，骨铅与年龄的回归模型未考虑不确定性。然而，在本文中，我们针对不确定性水平对骨铅值进行了调整。这对骨铅的回归模型有显著影响，因此我们建议在未来的研究中考虑不确定性。
