Li Gang, Ma Xingxing, Jia Chunqi, Han Qingqing, Wang Ya, Wang Junjie, Yu Liuyang, Yang Suling
College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455002, P. R. China.
Chem Commun (Camb). 2017 Jan 19;53(7):1261-1264. doi: 10.1039/c6cc09323j.
meta/ortho-Selective C-H (di)alkylation reactions of azoarenes have been achieved via [Ru(p-cymene)Cl] catalyzed ortho-metalation using various types of alkyl bromides. Particularly, dual meta-alkylation of azoarene and reduction offer an attractive strategy for the synthesis of meta-alkylanilines, which are difficult to access via traditional aniline functionalization methods.
通过[Ru(p - 异丙苯)Cl]催化的邻位金属化反应，利用各种类型的烷基溴化物实现了偶氮芳烃的间位/邻位选择性C-H（二）烷基化反应。特别地，偶氮芳烃的双间位烷基化和还原反应为间位烷基苯胺的合成提供了一种有吸引力的策略，而传统的苯胺官能化方法难以获得间位烷基苯胺。
