College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, P. R. China.
The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, Hangzhou, Zhejiang, P. R. China.
J Cell Physiol. 2017 Oct;232(10):2653-2656. doi: 10.1002/jcp.25786. Epub 2017 Apr 10.
Liver kinase B1 (Lkb1), also named as Serine/Threonine protein kinase 11 (STK11), is a serine/threonine kinase that plays crucial roles in various cellular processes including cell survival, cell division, cellular polarity, cell growth, cell differentiation, and cell metabolism. In metabolic tissues, Lkb1 regulates glucose homeostasis and energy metabolism through phosphorylating and activating the AMPK subfamily proteins. In skeletal muscle, Lkb1 affects muscle development and postnatal growth, lipid and fatty acid oxidation, glucose metabolism, and insulin sensitivity. Recently, the regulatory roles of Lkb1 in regulating division, self-renew, proliferation, and differentiation of skeletal muscle progenitor cells have been reported. In this review, we discuss the roles of Lkb1 in regulating skeletal muscle progenitor cell homeostasis and skeletal muscle development and metabolism.
肝激酶 B1（Lkb1），也称为丝氨酸/苏氨酸蛋白激酶 11（STK11），是一种丝氨酸/苏氨酸激酶，在包括细胞存活、细胞分裂、细胞极性、细胞生长、细胞分化和细胞代谢在内的各种细胞过程中发挥关键作用。在代谢组织中，Lkb1 通过磷酸化和激活 AMPK 亚家族蛋白来调节葡萄糖稳态和能量代谢。在骨骼肌中，Lkb1 影响肌肉发育和出生后生长、脂质和脂肪酸氧化、葡萄糖代谢和胰岛素敏感性。最近，已有报道称 Lkb1 在调节骨骼肌祖细胞的分裂、自我更新、增殖和分化中起调节作用。在这篇综述中，我们讨论了 Lkb1 在调节骨骼肌祖细胞动态平衡和骨骼肌发育和代谢中的作用。
