Rogers S J, Newhart-Larson S
Department of Psychiatry, University of Colorado Health Sciences Center, Denver 80262.
Dev Med Child Neurol. 1989 Oct;31(5):598-608. doi: 10.1111/j.1469-8749.1989.tb04045.x.
The behavioral characteristics of five preschool boys with Leber's congenital amaurosis were compared with those of five preschool boys who had been blind from birth from other causes. The boys with Leber's amaurosis met criteria for infantile autism and had remarkably similar developmental histories. They had significantly higher ratings on the Childhood Autism Rating Scale for both frequency and severity of autistic symptoms. The two groups also had different profiles on the Autism Behavior Checklist, the Leber group having a distinctive profile and higher scores. It is suggested that cases of Leber's amaurosis may account for some descriptions in the literature of the co-occurrence of autistic behavior and blindness in children. Deficits in cerebellar structure have been reported in some Leber patients and in some autistic children, which may provide the neurological basis for the behavioral similarities seen in children with Leber's amaurosis and sighted autistic children.
将五名患有莱伯先天性黑蒙的学龄前男孩的行为特征与五名因其他原因自幼失明的学龄前男孩的行为特征进行了比较。患有莱伯黑蒙的男孩符合婴儿自闭症的标准，并且有着显著相似的发育史。他们在儿童自闭症评定量表上的自闭症症状频率和严重程度评分显著更高。两组在自闭症行为清单上也有不同的表现，莱伯组有独特的表现且得分更高。有人提出，莱伯先天性黑蒙病例可能解释了文献中关于儿童自闭症行为与失明同时出现的一些描述。在一些莱伯病患者和一些自闭症儿童中报告了小脑结构缺陷，这可能为患有莱伯先天性黑蒙的儿童和有视力的自闭症儿童行为相似性提供神经学基础。
