Matard Bruno, Cavelier-Balloy Benedicte, Reygagne Pascal
Hôpital Saint-Louis, Centre Sabouraud, Paris, France.
Department of Dermatopathology, Policlinique Hôpital Saint Louis, Paris, France.
J Cutan Pathol. 2017 Apr;44(4):352-357. doi: 10.1111/cup.12892. Epub 2017 Jan 27.
Follicular hyperkeratosis along with hyperplasia of the follicular and interfollicular epithelia are major histopathological characteristics of hidradenitis suppurativa (HS). The presence of an occasional thickening of lesional skin in some folliculitis decalvans (FD) patients and histological similarities between FD and HS led us to look for epidermal hyperplasia and follicular hyperkeratosis in FD patients.
We performed a retrospective histological analysis of 26 patients with FD.
We sought to find out whether the presence of hyperplasia of the interfollicular epidermis and of the follicular epithelia could be verified in FD, with reference to the work of von Laffert et al. concerning HS.
The main quantitative and qualitative data were: follicular hyperkeratosis (77%), hyperplasia of the interfollicular epidermis (92%) with a psoriasiform aspect (88%), atrophy of the follicular epithelia (85%), plasma cells in infiltrate (92%) in large quantities (42%), follicular microcysts (60%), atrophy of the sebaceous glands (85%) and polytrichia (54%).
Epidermal hyperplasia, sometimes psoriasiform and follicular microcysts, are significant histological signs of FD, which have been ignored until now although they seem very common.
毛囊角化过度以及毛囊和毛囊间上皮增生是化脓性汗腺炎（HS）的主要组织病理学特征。一些脱发性毛囊炎（FD）患者病变皮肤偶尔出现增厚，且FD与HS在组织学上存在相似性，这促使我们在FD患者中寻找表皮增生和毛囊角化过度的情况。
我们对26例FD患者进行了回顾性组织学分析。
参照冯·拉费特等人关于HS的研究，我们试图查明在FD中是否能证实毛囊间表皮和毛囊上皮存在增生。
主要的定量和定性数据如下：毛囊角化过度（77%）、毛囊间表皮增生（92%）且呈银屑病样外观（88%）、毛囊上皮萎缩（85%）、浸润中有大量浆细胞（92%）（42%）、毛囊微囊肿（60%）、皮脂腺萎缩（85%）以及多毛症（54%）。
表皮增生，有时呈银屑病样以及毛囊微囊肿，是FD重要的组织学征象，但至今一直被忽视，尽管它们似乎很常见。
