Boulloche J, Leloup P, Mallet E, Parain D, Tron P
Paediatric Unit, Hôpital Charles Nicolle, Rouen, France.
Dev Med Child Neurol. 1989 Oct;31(5):626-32. doi: 10.1111/j.1469-8749.1989.tb04048.x.
A cohort of 119 two- to 16-year-old patients was followed to assess the risk of recurrence after a single, unprovoked, generalized tonic-clonic seizure. Only children with a normal neurological examination and intellectual development, and an EEG showing no focal abnormality, were studied. The risk of recurrence at six months was 22 per cent, at one year 28.5 per cent, at three years 32.6 per cent and at eight years 37.7 per cent. 58 per cent of recurrences occurred within the first six months and 87 per cent within the first two years. Initial EEGs showing generalized, unprovoked spikes and waves, generalized paroxysmal discharges precipitated by intermittent photic stimulation, or isolated slowing, were associated with risks of recurrence at two years of 40, 50 and 26 per cent, respectively. These results do not differ significantly from those obtained when the initial EEG was normal (29 per cent). Age, seizure duration and history of epilepsy in the family were not associated with a significantly higher risk of recurrence. The risk of recurrence was similar for treated and untreated patients.
对119名2至16岁的患者进行了随访，以评估单次无诱因全身性强直阵挛发作后的复发风险。仅研究了神经学检查和智力发育正常且脑电图无局灶性异常的儿童。六个月时的复发风险为22%，一年时为28.5%，三年时为32.6%，八年时为37.7%。58%的复发发生在头六个月内，87%发生在头两年内。初始脑电图显示全身性、无诱因的棘波和慢波、由间歇性光刺激诱发的全身性阵发性放电或孤立性减慢，其两年复发风险分别为40%、50%和26%。这些结果与初始脑电图正常时（29%）获得的结果无显著差异。年龄、发作持续时间和家族癫痫病史与显著更高的复发风险无关。治疗和未治疗患者的复发风险相似。
