雄激素受体在三阴性乳腺癌中的表达及临床意义
Expression and Clinical Significance of Androgen Receptor in Triple-Negative Breast Cancer.
作者信息
Asano Yuka, Kashiwagi Shinichiro, Goto Wataru, Tanaka Sayaka, Morisaki Tamami, Takashima Tsutomu, Noda Satoru, Onoda Naoyoshi, Ohsawa Masahiko, Hirakawa Kosei, Ohira Masaichi
机构信息
Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan.
Department of Diagnostic Pathology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan.
出版信息
Cancers (Basel). 2017 Jan 6;9(1):4. doi: 10.3390/cancers9010004.
BACKGROUND
Triple-negative breast cancer (TNBC) has a poor prognosis because of frequent recurrence. Androgen receptor (AR) is involved in the pathogenesis of breast cancer, but its role is not clearly defined. The aim of this study was to explore the expression of AR and its relationship with clinicopathologic features in TNBC.
METHODS
This study investigated 1036 cases of sporadic invasive breast carcinoma. Immunohistochemical assays were performed to determine the expression of AR in 190 TNBC samples. The relationships between AR expression and clinicopathologic data and prognosis were analyzed.
RESULTS
In 190 TNBC cases, the prognosis of AR-positive patients was significantly better ( = 0.019, log-rank) than AR-negative patients, and in multivariate analysis, AR expression was an independent indicator of good prognosis ( = 0.039, hazard ratio = 0.36). In patients with disease relapse, AR positivity was significantly correlated with better prognosis ( = 0.034, log-rank).
CONCLUSIONS
AR expression may be useful as a subclassification marker for prognosis in TNBC.
背景
三阴性乳腺癌（TNBC）因频繁复发，预后较差。雄激素受体（AR）参与乳腺癌的发病机制，但其作用尚未明确界定。本研究旨在探讨TNBC中AR的表达及其与临床病理特征的关系。
方法
本研究调查了1036例散发性浸润性乳腺癌病例。采用免疫组织化学方法检测190例TNBC样本中AR的表达。分析AR表达与临床病理数据及预后的关系。
结果
在190例TNBC病例中，AR阳性患者的预后明显优于AR阴性患者（P = 0.019，对数秩检验），多因素分析显示，AR表达是良好预后的独立指标（P = 0.039，风险比 = 0.36）。在疾病复发的患者中，AR阳性与较好的预后显著相关（P = 0.034，对数秩检验）。
结论
AR表达可能作为TNBC预后的一种亚分类标志物。
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