来自台湾柳珊瑚Pinnigorgia sp.（柳珊瑚科）的新型11-乙酰氧基-9,11-断甾体类化合物——平尼甾醇D-J，含1,4-醌部分

Pinnisterols D-J, New 11-Acetoxy-9,11-secosterols with a 1,4-Quinone Moiety from Formosan Gorgonian Coral Pinnigorgia sp. (Gorgoniidae).

作者信息

Chang Yu-Chia, Hwang Tsong-Long, Kuo Liang-Mou, Sung Ping-Jyun

机构信息

National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan.

Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan.

出版信息

Mar Drugs. 2017 Jan 6;15(1):11. doi: 10.3390/md15010011.

Seven new marine 11-acetoxy-9,11-secosterols, pinnisterols D-J (-), with a 1,4-quinone moiety, were discovered from the gorgonian coral sp. In this study, the structures of secosterols - were revealed by spectroscopic analysis. Bioactivity study showed that secosterol treatment inhibited cell viability in a hepatic stellate cell line, HSC-T6, with an IC value of 3.93 μM; and secosterols , , and reduced elastase enzyme release, and , , and decreased the production of superoxide anions from human neutrophils.