A.V. Zhirmunsky National Scientific Center of Marine Biology, 17 Palchevsky Str., 690041 Vladivostok, Russia.
Institute of Biomedical Chemistry, bldg. 8, 10 Pogodinskaya Str., 119121 Moscow, Russia.
Mar Drugs. 2020 Dec 2;18(12):613. doi: 10.3390/md18120613.
The review is devoted to the chemical diversity of steroids produced by soft corals and their determined and potential activities. There are about 200 steroids that belong to different types of steroids such as secosteroids, spirosteroids, epoxy- and peroxy-steroids, steroid glycosides, halogenated steroids, polyoxygenated steroids and steroids containing sulfur or nitrogen heteroatoms. Of greatest interest is the pharmacological activity of these steroids. More than 40 steroids exhibit antitumor and related activity with a confidence level of over 90 percent. A group of 32 steroids shows anti-hypercholesterolemic activity with over 90 percent confidence. Ten steroids exhibit anti-inflammatory activity and 20 steroids can be classified as respiratory analeptic drugs. Several steroids exhibit rather rare and very specific activities. Steroids exhibit anti-osteoporotic properties and can be used to treat osteoporosis, as well as have strong anti-eczemic and anti-psoriatic properties and antispasmodic properties. Thus, this review is probably the first and exclusive to present the known as well as the potential pharmacological activities of 200 marine steroids.
这篇综述致力于探讨软珊瑚产生的甾体化合物的化学多样性及其已确定和潜在的活性。约有 200 种甾体化合物属于不同类型，如甾族化合物、螺甾族化合物、环氧和过氧甾体、甾体糖苷、卤化甾体、多氧化甾体以及含硫或氮杂原子的甾体。这些甾体化合物最引人关注的是其药理活性。超过 40 种甾体化合物具有抗肿瘤及相关活性，置信度超过 90%。有一组 32 种甾体化合物具有抗高胆固醇血症的活性，置信度超过 90%。10 种甾体化合物具有抗炎活性，20 种甾体化合物可归类为呼吸兴奋剂。一些甾体化合物具有相当罕见和非常特殊的活性。甾体化合物具有抗骨质疏松特性，可用于治疗骨质疏松症，同时具有很强的抗湿疹、抗银屑病和抗痉挛特性。因此，这篇综述可能是第一篇也是唯一一篇介绍 200 种海洋甾体化合物已知和潜在药理活性的综述。
