Hamilton B K, Goje O, Savani B N, Majhail N S, Stratton P
Blood &Marrow Transplant Program, Hematology and Medical Oncology, Cleveland Clinic, Taussig Cancer Institute, Cleveland, OH, USA.
Obstetrics and Gynecology, Cleveland Clinic, Cleveland, OH, USA.
Bone Marrow Transplant. 2017 Jun;52(6):803-810. doi: 10.1038/bmt.2016.315. Epub 2017 Jan 9.
Chronic GvHD (cGvHD) of the genital tract is an underreported and infrequently recognized complication of allogeneic hematopoietic cell transplantation in both male and female long-term survivors. Its pathophysiology, clinical manifestations and management are not well understood, and studies are limited. We thus provide a comprehensive review of genital cGvHD in both men and women, as well as discuss related issues of sexual health and viral reactivation. We further provide guidance on screening, management and long-term follow-up, as well as future priority areas of study.
生殖道慢性移植物抗宿主病（cGvHD）是同种异体造血细胞移植在男性和女性长期存活者中一种报道不足且很少被认识到的并发症。其病理生理学、临床表现及治疗尚不清楚，相关研究有限。因此，我们对男性和女性的生殖器cGvHD进行了全面综述，并讨论了性健康和病毒再激活的相关问题。我们还提供了关于筛查、治疗和长期随访的指导，以及未来的优先研究领域。
