CIBMTR® (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Division of Pediatric Hematology/Oncology/Blood and Marrow Transplant, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.
Bone Marrow Transplant. 2022 Jul;57(7):1150-1163. doi: 10.1038/s41409-022-01591-z. Epub 2022 May 6.
Male-specific late effects after hematopoietic cell transplantation (HCT) include genital chronic graft-versus-host disease (GvHD), hypogonadism, sexual dysfunction, infertility, and subsequent malignancies. They may be closely intertwined and cause prolonged morbidity and decreased quality of life after HCT. We provide a systematic review of male-specific late effects in a collaboration between transplant physicians, endocrinologists, urologists, dermatologists, and sexual health professionals through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research, and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. The systematic review summarizes incidence, risk factors, screening, prevention and treatment of these complications and provides consensus evidence-based recommendations for clinical practice and future research.
男性造血细胞移植（HCT）后的特定晚期效应包括生殖器慢性移植物抗宿主病（GvHD）、性腺功能减退、性功能障碍、不育症和随后的恶性肿瘤。这些问题可能密切相关，导致 HCT 后长期发病和生活质量下降。我们通过国际血液和骨髓移植研究中心的晚期效应和生活质量工作组以及欧洲血液和骨髓移植学会的移植并发症工作组，组织移植医生、内分泌学家、泌尿科医生、皮肤科医生和性健康专家合作，对男性特定晚期效应进行了系统评价。该系统评价总结了这些并发症的发生率、危险因素、筛查、预防和治疗，并为临床实践和未来研究提供了基于共识的循证建议。
