Besheer Tarek, El-Bendary Mahmoud, Elalfy Hatem, Abd El-Maksoud Mohamed, Salah Mohamed, Zalata Khaled, Elkashef Wagdi, Elshahawy Heba, Raafat Doaa, Elemshaty Wafaa, Almashad Noha, Zaghloul Hosam, El-Gilany Abdel-Hady, Abdel Razek Ahmed Abdel Khalek, Abd Elwahab Mohamed
1 Department of Tropical Medicine, Mansoura University , Mansoura, Egypt .
2 Department of Pathlogy, Mansoura University , Mansoura, Egypt .
J Interferon Cytokine Res. 2017 Mar;37(3):97-102. doi: 10.1089/jir.2016.0111. Epub 2017 Jan 9.
The rate of liver fibrosis progression in chronic hepatitis C (CHC) patients is highly variable and affected by different factors. This study aimed to assess the role of cirrhosis risk score (CRS) based on 7 genetic variants (7 single-nucleotide polymorphisms [SNPs]) and host factors (age and sex) in the prediction of the rate of fibrosis progression in CHC. Duration of infection was determined in 115 patients. The fibrosis progression rate (FPR) per year was calculated as the ratio between fibrosis stage and the duration of infection. SNP genotyping were performed and CRS was determined based on it. FPR was significantly elevated in patients who acquired infection at age >40 years versus those who acquired infection at 30-40 years and those who acquired infection at <30 years. Median FPR was significantly higher in males than females (0.17 vs. 0.15) with P = 0.001. CRS value ≥0.8 is predictive of patients with high risk for cirrhosis, and CRS value <0.5 is predictive of patients with low risk for cirrhosis. There was significant positive correlation between CRS and FPR (P ≤ 0.001). CRS based on 7 SNPs at cutoff value ≥0.8, age at infection >40 years, and male sex are predictors of higher FPR.
慢性丙型肝炎（CHC）患者的肝纤维化进展速率高度可变，且受不同因素影响。本研究旨在评估基于7种基因变异（7个单核苷酸多态性[SNPs]）和宿主因素（年龄和性别）的肝硬化风险评分（CRS）在预测CHC患者肝纤维化进展速率中的作用。对115例患者的感染持续时间进行了测定。每年的纤维化进展速率（FPR）计算为纤维化分期与感染持续时间的比值。进行了SNP基因分型，并据此确定了CRS。与30 - 40岁感染患者及<30岁感染患者相比，>40岁感染患者的FPR显著升高。男性的中位FPR显著高于女性（0.17对0.15），P = 0.001。CRS值≥0.8可预测肝硬化高风险患者，CRS值<0.5可预测肝硬化低风险患者。CRS与FPR之间存在显著正相关（P≤0.001）。基于7个SNP的CRS在临界值≥0.8、感染时年龄>40岁以及男性是较高FPR的预测因素。
