Berry Lisa, Stanley Belinda
Department of Virology and Molecular Pathology, Coventry and Warwickshire Pathology Services, University Hospitals Coventry and Warwickshire NHS Trust, Clifford Bridge Road, Coventry CV2 2DX, UK.
Integrated Sexual Health Services, Coventry and Warwickshire Partnership NHS Trust, City of Coventry Health Centre, Stoney Stanton Road, Coventry CV1 4FS, UK.
J Med Microbiol. 2017 Feb;66(2):134-136. doi: 10.1099/jmm.0.000428. Epub 2017 Mar 7.
Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) are common bacterial causes of sexually transmitted infections. Self-taken meatal swabs are a possible alternative to urine samples in testing for infection; however, the data surrounding their use are limited.
We carried out a prospective service review in a large sexual health clinic comparing urine samples and self-taken meatal swabs in men presenting for sexual transmissible infection screening for CT and GC with the BD Viper XTR system.
We found an overall prevalence of 10.5 % for CT infections and 4.2 % for GC infections in our patient population. Meatal swab testing had a sensitivity and specificity of 91 and 99 % with an negative predictive value (NPV) of 99 % and a positive predictive value (PPV) of 96 % for CT testing compared to a sensitivity and specificity of 100 and 99 % with an NPV of 100 % and a PPV of 98 % for urine samples. The sensitivity and specificity of meatal swabs was 100 and 99 %, respectively, for GC detection with an NPV of 100 % and PPV of 89 % compared to urine which had 93 % sensitivity and 99 % specificity with an NPV and PPV of 99 and 93 %, respectively.
Meatal samples were not inferior to urine samples for the detection of CT and GC. Male urethral meatal self-sampling offers an alternative sample type when compared to male urine specimens.
沙眼衣原体（CT）和淋病奈瑟菌（GC）是性传播感染常见的细菌病因。自行采集尿道口拭子是检测感染时尿液样本的一种可能替代方法；然而，关于其使用的数据有限。
我们在一家大型性健康诊所进行了一项前瞻性服务评估，使用BD Viper XTR系统比较前来进行CT和GC性传播感染筛查的男性的尿液样本和自行采集的尿道口拭子。
我们发现患者群体中CT感染的总体患病率为10.5%，GC感染为4.2%。尿道口拭子检测CT的敏感性和特异性分别为91%和99%，阴性预测值（NPV）为99%，阳性预测值（PPV）为96%；相比之下，尿液样本的敏感性和特异性分别为100%和99%，NPV为100%，PPV为98%。检测GC时，尿道口拭子的敏感性和特异性分别为100%和99%，NPV为100%，PPV为89%；而尿液的敏感性为93%，特异性为99%，NPV和PPV分别为99%和93%。
在检测CT和GC方面，尿道口样本并不逊色于尿液样本。与男性尿液标本相比，男性尿道尿道口自行采样提供了另一种样本类型。
