Rattan A K, Mangat H K
Neuroscience Research Laboratory, School of Life Sciences, Guru Nanak Dev University, Amritsar, India.
Gegenbaurs Morphol Jahrb. 1989;135(3):397-405.
In the present study, the effect of intracerebroventricular (icv) injection of GABA, its agonist--muscimol, and antagonist--picrotoxin, has been studied on histoenzymological alterations of acetylcholinesterase (AChE). butyrylcholinesterase (BuChE), monoamine oxidase (MAO), and succinic dehydrogenase (SDH) by cytophotometric technique. This study was conducted on medial preoptic area (mPOA), nucleus paraventricularis hypothalami (PVH), area lateralis hypothalami (LHA), nucleus dorsomedialis hypothalami (DMH), and nucleus ventromedialis hypothalami (VMH). Results showed that GABA and muscimol inhibited AChE, BuChE, MAO, and SDH in all the areas while picrotoxin stimulated these enzymes. These changes in enzyme activity by GABA, muscimol, and picrotoxin and their possible mode of action are discussed.
在本研究中，通过细胞光度测定技术，研究了脑室内注射γ-氨基丁酸（GABA）、其激动剂蝇蕈醇和拮抗剂印防己毒素对乙酰胆碱酯酶（AChE）、丁酰胆碱酯酶（BuChE）、单胺氧化酶（MAO）和琥珀酸脱氢酶（SDH）组织酶学改变的影响。本研究在视前内侧区（mPOA）、下丘脑室旁核（PVH）、下丘脑外侧区（LHA）、下丘脑背内侧核（DMH）和下丘脑腹内侧核（VMH）进行。结果表明，GABA和蝇蕈醇在所有区域均抑制AChE、BuChE、MAO和SDH，而印防己毒素则刺激这些酶。讨论了GABA、蝇蕈醇和印防己毒素引起的酶活性变化及其可能的作用方式。
