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[向大鼠中枢给予γ-氨基丁酸激动剂和拮抗剂时海马体的电活动]

[The electrical activity of the hippocampus in rats centrally administered GABA agonists and antagonists].

作者信息

Iarkov A V, Vorob'ev V V, Gal'chenko A A, Kovalev G I

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1989 Dec;75(12):1677-85.

PMID:2560722
Abstract

In unrestrained rats, frequency ranges of dorsal hippocampus electrograms were studied after intraventricular injections of the GABA, muscimol, baclofen, bicuculline and picrotoxin. The data obtained corroborates the idea of an interrelationship between the agonists and antagonists of the GABA receptors. A possibility of participation of these receptors in the formation and/or modulation of total electrical hippocampal activity, is discussed.

摘要

在未受限制的大鼠中,在脑室内注射γ-氨基丁酸(GABA)、蝇蕈醇、巴氯芬、荷包牡丹碱和印防己毒素后,研究了背侧海马电图的频率范围。所获得的数据证实了GABA受体激动剂和拮抗剂之间存在相互关系的观点。讨论了这些受体参与海马总体电活动形成和/或调节的可能性。

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