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体外受精后单卵双胞胎及双胞胎特异性异常是否更为普遍?对埃尔朗根 - 纽伦堡大学妇科诊所研究的评论

[Are monozygous twins and twin-specific abnormalities more prevalent following extracorporeal fertilization? A comment on studies of the Gynecologic Clinic of the Erlangen-Nürnberg University].

作者信息

Pfeiffer R A, Van Uem J F, Siebzehnrübl E, Wildt L

机构信息

Institut für Humangenetik der Friedrich-Alexander-Universität Erlangen-Nürnberg.

出版信息

Geburtshilfe Frauenheilkd. 1989 Sep;49(9):813-6. doi: 10.1055/s-2008-1036091.

DOI:10.1055/s-2008-1036091
PMID:2806854
Abstract

IVF was performed in the Department of Gynecology and Obstetrics, University of Erlangen-Nürnberg, and monozygotic twins were established in one case, but were indicated in two more cases. In further two cases one sexlike twin had died from caudal regression. This malformation complex, which has been noted very occasionally in monozygotic twins, is considered to be related to the twinning process. The question is raised, as to whether after IVF monozygotic twins are expected more frequently. Furthermore the importance of this question is discussed with reference to recent observations in twin research.

摘要

体外受精在埃尔朗根 - 纽伦堡大学妇产科进行,其中一例成功孕育出单卵双胞胎,另有两例也出现了单卵双胞胎迹象。还有另外两例中,一个类同性双胞胎因尾部退化而死亡。这种畸形组合在单卵双胞胎中极为罕见,被认为与双胞胎形成过程有关。由此引发一个问题,即体外受精后单卵双胞胎的出现频率是否会更高。此外,结合双胞胎研究的最新观察结果讨论了这个问题的重要性。

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