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使用MAST在重复性实验室应激诱导过程中检查习惯化和敏感化。

Examining habituation and sensitization across repetitive laboratory stress inductions using the MAST.

作者信息

Quaedflieg C W E M, Meyer T, van Ruitenbeek P, Smeets T

机构信息

Department of Cognitive Psychology, Institute for Psychology, University of Hamburg, Germany; Faculty of Psychology and Neuroscience, Maastricht University, The Netherlands.

Faculty of Psychology and Neuroscience, Maastricht University, The Netherlands; Behavioral Science Institute, Radboud University Nijmegen, The Netherlands.

出版信息

Psychoneuroendocrinology. 2017 Mar;77:175-181. doi: 10.1016/j.psyneuen.2016.12.009. Epub 2016 Dec 23.

DOI:10.1016/j.psyneuen.2016.12.009
PMID:28068575
Abstract

Reliably eliciting acute stress repeatedly over time is of indispensable value for research into stress vulnerability and for developing interventions aimed at increasing stress resiliency. Here, we evaluated whether the Maastricht Acute Stress Test (MAST), a potent stress protocol that combines physical and psychosocial stress components, can be used to reliably elicit subjective and neuroendocrine stress responses multiple times. Sixty healthy undergraduate participants were exposed to the MAST on three occasions, with intervals of three-weeks and one-month in between sessions. Results showed no significant signs of habituation or sensitization to the MAST in terms of subjective or physiological (salivary alpha-amylase and cortisol) stress reactivity. Fifty-nine percent of the sample displayed a significant physiological stress response (i.e., cortisol) to two MAST exposures and 57% to every MAST exposure. This study demonstrates that the MAST can be used to repeatedly induce significant stress responses.

摘要

随着时间的推移,可靠地反复引发急性应激对于应激易感性研究以及开发旨在提高应激恢复力的干预措施具有不可或缺的价值。在此,我们评估了马斯特里赫特急性应激测试(MAST),这是一种结合了身体和心理社会应激成分的有效应激方案,是否可用于多次可靠地引发主观和神经内分泌应激反应。60名健康的本科参与者分三次接受MAST测试,每次测试间隔三周和一个月。结果显示,在主观或生理(唾液α-淀粉酶和皮质醇)应激反应性方面,对MAST没有明显的习惯化或敏感化迹象。59%的样本对两次MAST暴露表现出显著的生理应激反应(即皮质醇),57%的样本对每次MAST暴露都有反应。这项研究表明,MAST可用于反复诱导显著的应激反应。

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