Activ'Inside, F-33750 Beychac et Caillau, France.
Hormone Laboratory, Nuclear Medicine, CHU Bordeaux, UMR INRA 1286, University Bordeaux, F-33000 Bordeaux, France.
Nutrients. 2023 Jun 27;15(13):2921. doi: 10.3390/nu15132921.
According to animal studies, saffron and its main volatile compound safranal may reduce biological and behavioral signs of acute stress. However, little is known about its impact in humans. This study investigated the acute effect of a saffron extract and safranal on the biological and psychological stress responses in healthy men experiencing a laboratory stress procedure. In this double-blind, placebo-controlled, randomized, cross-over study, 19 volunteers aged 18-25 received a single dose of 30 mg saffron extract (Safr'Inside, 0.06 mg synthetic safranal, or a placebo on three visits separated by a 28-day washout. Thirteen minutes after administration, participants were exposed to the Maastricht acute stress test (MAST). Salivary cortisol and cortisone were collected from 15 min before the MAST (and pre-dose), 3 min before the MAST, and then 15, 30, 45, 60, and 75 min after the MAST, and stress and anxiety were measured using visual analogic scales. Compared to the placebo, stress and anxiety were significantly toned down after Safranal and Safr'Inside administration and coupled with a delay in the times to peak salivary cortisol and cortisone concentrations ( < 0.05). Safr'Inside and its volatile compound seem to improve psychological stress response in healthy men after exposure to a lab-based stressor and may modulate the biological stress response.
根据动物研究，藏红花及其主要挥发性化合物藏红花醛可能会减轻急性应激的生物学和行为迹象。然而，关于其在人类中的影响知之甚少。本研究调查了藏红花提取物和藏红花醛对经历实验室应激程序的健康男性的生物学和心理应激反应的急性影响。在这项双盲、安慰剂对照、随机、交叉研究中，19 名年龄在 18-25 岁的志愿者在三次就诊中分别接受了 30 毫克藏红花提取物（Safr'Inside，0.06 毫克合成藏红花醛或安慰剂）的单次剂量，两次就诊之间间隔 28 天洗脱期。给药后 13 分钟，参与者接受了马斯特里赫特急性应激测试（MAST）。在 MAST 之前 15 分钟（和预剂量）、MAST 之前 3 分钟以及 MAST 之后 15、30、45、60 和 75 分钟收集唾液皮质醇和皮质酮，并使用视觉模拟量表测量应激和焦虑。与安慰剂相比，Safranal 和 Safr'Inside 给药后应激和焦虑明显减轻，并且唾液皮质醇和皮质酮浓度达到峰值的时间延迟（<0.05）。Safr'Inside 和其挥发性化合物似乎可以改善暴露于基于实验室的应激源后的健康男性的心理应激反应，并可能调节生物应激反应。
