Milner Allison, Witt Katrina, Pirkis Jane, Hetrick Sarah, Robinson Jo, Currier Dianne, Spittal Matthew J, Page Andrew, Carter Gregory L
Centre for Health Equity, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia; Work, Health and Wellbeing Unit, Population Health Research Centre, School of Health & Social Development, Deakin University, Melbourne, Australia.
Turning Point, Monash University, Melbourne, Australia.
J Affect Disord. 2017 Mar 1;210:294-302. doi: 10.1016/j.jad.2016.12.035. Epub 2016 Dec 24.
The aim of this review was to assess whether suicide prevention provided in the primary health care setting and delivered by GPs results in fewer suicide deaths, episodes of self-harm, attempts and lower frequency of thoughts about suicide.
We conducted a systematic review and meta-analysis using PRIMSA guidelines. Eligible studies: 1) evaluated an intervention provided by GPs; 2) assessed suicide, self-harm, attempted suicide or suicide ideation as outcomes, and; 3) used a quasi-experimental observational or trial design. Study specific effect sizes were combined using the random effects meta-analysis, with effects transformed into relative risk (RR).
We extracted data from 14 studies for quantitative meta-analysis. The RR for suicide death in quasi-experimental observational studies comparing an intervention region against another region acting as a "control" was 1.26 (95% CI 0.58, 2.74). When suicide in the intervention region was compared before and after the GP program, the RR was 0.78 (95% CI 0.62, 0.97). There was no evidence of a treatment effect for GP training on rates of suicide death in one cRCT (RR 1.07, 95% CI 0.79, 1.45). There was no evidence of effect for the most other outcomes studied.
All of the studies included in this review are likely to have a high level of bias. It is also possible that we excluded or missed relevant studies in our review process CONCLUSIONS: Interventions have produced equivocal results, which varied by study design and outcome. Given these results, we cannot recommend the roll out of GP suicide prevention initiatives.
本综述的目的是评估在初级卫生保健环境中由全科医生提供的自杀预防措施是否能减少自杀死亡人数、自伤事件、自杀未遂情况以及降低自杀念头的发生频率。
我们按照PRISMA指南进行了系统综述和荟萃分析。符合条件的研究:1)评估了全科医生提供的干预措施;2)将自杀、自伤、自杀未遂或自杀意念作为结局进行评估;3)采用了准实验性观察或试验设计。使用随机效应荟萃分析合并各研究的效应量,并将效应转化为相对风险(RR)。
我们从14项研究中提取数据进行定量荟萃分析。在将干预地区与作为“对照”的另一地区进行比较的准实验性观察研究中,自杀死亡的RR为1.26(95%置信区间0.58,2.74)。当比较全科医生项目实施前后干预地区的自杀情况时,RR为0.78(95%置信区间0.62,0.97)。在一项随机对照临床试验中,没有证据表明全科医生培训对自杀死亡率有治疗效果(RR 1.07,95%置信区间0.79,1.45)。对于其他大多数研究的结局,也没有证据表明有效果。
本综述纳入的所有研究可能都存在高度偏倚。在我们的综述过程中,也有可能排除或遗漏了相关研究。结论:干预措施产生了不明确的结果,这些结果因研究设计和结局而异。鉴于这些结果,我们不能建议推广全科医生自杀预防倡议。