Gimelfarb A
Department of Ecology and Evolution, University of Chicago, Illinois 60637.
Genetics. 1989 Sep;123(1):217-27. doi: 10.1093/genetics/123.1.217.
A model of the gene action on a quantitative character is suggested. The model takes into account epistasis by combining multiplicative with the traditional additive approximation of the action of loci. It is demonstrated on the basis of this model that a high level of genotypic variation can be maintained in a population for a quantitative character under stabilizing selection in the absence of mutations, if there is epistasis. It is also shown that a large amount of additive variation as well as high heritability can be "hidden" in such a population and "released" if stabilizing selection is relaxed.
提出了一个关于数量性状基因作用的模型。该模型通过将位点作用的乘法近似与传统的加性近似相结合来考虑上位性。基于此模型证明，如果存在上位性，在没有突变的情况下，对于数量性状，稳定选择下群体中可以维持高水平的基因型变异。还表明，在这样的群体中，大量的加性变异以及高遗传力可能会“隐藏”起来，而当稳定选择放松时会“释放”出来。
