Weber Klaus
1 AnaPath GmbH, Oberbuchsiten, Switzerland.
Toxicol Pathol. 2017 Jan;45(1):64-75. doi: 10.1177/0192623316672075.
A substantial quantity of data on Sprague-Dawley (SD) and Hannover Wistar rats strains have been published concerning their source, diet, and housing conditions, as well as the incidences of nonneoplastic lesions and neoplasms observed in different laboratories. Differences between the commonly used rat strains provided by different breeders (i.e., CD (SD) vs. Harlan Sprague-Dawley strain or Crl: WI(Han) vs. Wistar Hannover (Han)-derived strain, continued breeding by RCC Ltd., Switzerland, thereafter continued breeding by Harlan) may include, but are not limited to, body weight, incidence, and onset of major nonneoplastic lesions and neoplasms, and these can impact the development of a nonclinical safety program. Fisher 344 (F344) and SD rat strains generally have the highest tumor incidences, exceeding that in Wistar rats. Certain tumors are more commonly observed in one strain, and for some, the difference in incidence may be so significant that the tumor may even be considered characteristic for a specific strain (e.g., thymoma in Wistar and amphophilic renal adenoma in SD).
关于斯普拉格-道利（SD）大鼠和汉诺威威斯塔大鼠品系的大量数据已被发表，内容涉及它们的来源、饮食和饲养条件，以及在不同实验室观察到的非肿瘤性病变和肿瘤的发生率。不同繁育者提供的常用大鼠品系之间的差异（即CD（SD）与哈兰斯普拉格-道利品系，或Crl:WI（Han）与威斯塔汉诺威（Han）衍生品系，最初由瑞士RCC有限公司持续繁育，此后由哈兰持续繁育）可能包括但不限于体重、主要非肿瘤性病变和肿瘤的发生率及发病时间，而这些会影响非临床安全性研究计划的制定。费希尔344（F344）大鼠和SD大鼠品系通常肿瘤发生率最高，超过威斯塔大鼠。某些肿瘤在一个品系中更常见，对于一些肿瘤而言，发生率的差异可能非常显著，以至于该肿瘤甚至可被视为特定品系的特征性肿瘤（例如威斯塔大鼠中的胸腺瘤和SD大鼠中的嗜酸性肾腺瘤）。
