Gow Adam G
Hospital for Small Animals, Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Easter Bush, Edinburgh EH25 9RG, Scotland.
Vet Clin North Am Small Anim Pract. 2017 May;47(3):585-599. doi: 10.1016/j.cvsm.2016.11.008. Epub 2017 Jan 6.
This article reviews hepatic encephalopathy (HE) in companion animals. Clinical signs and categories of hepatic disease likely to cause HE are discussed. Ammonia has a key role in pathogenesis and current concepts in body ammonia metabolism are reviewed. Inflammation and manganese accumulation are also thought to be important in pathogenesis. Treatment of HE in acute and chronic cases is discussed along with the rationale for current treatment recommendations. Potential avenues for new treatments and human treatments, which may be transferable to companion animals, are reviewed.
本文综述了伴侣动物的肝性脑病（HE）。讨论了可能导致HE的肝病临床症状和类别。氨在发病机制中起关键作用，并对目前体内氨代谢的概念进行了综述。炎症和锰蓄积在发病机制中也被认为很重要。文中讨论了急性和慢性病例中HE的治疗方法以及当前治疗建议的依据。还综述了可能适用于伴侣动物的新治疗方法和人类治疗方法的潜在途径。
