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一只患有门体分流的幼龄犬疑似肝性脑病的脑电图特征——病例报告

Electroencephalographic Features of Presumed Hepatic Encephalopathy in a Pediatric Dog with a Portosystemic Shunt-A Case Report.

作者信息

Ștefănescu Raluca Adriana, Boghian Vasile, Solcan Gheorghe, Codreanu Mario Darius, Musteata Mihai

机构信息

Neurology Service, Faculty of Veterinary Medicine, "Ion Ionescu de la Brad" Iași University of Life Sciences, 700489 Iași, Romania.

Internal Medicine Clinic, Faculty of Veterinary Medicine, "Ion Ionescu de la Brad" Iași University of Life Sciences, 8 M. Sadoveanu Alley, 700489 Iași, Romania.

出版信息

Life (Basel). 2025 Jan 16;15(1):107. doi: 10.3390/life15010107.

Abstract

Hepatic encephalopathy (HE) in dogs is a metabolic disorder of the central nervous system that occurs secondarily to liver dysfunctions, whether due to acquired or congenital causes. A portosystemic shunt is the presence of abnormal communications between the hepatic vessels (portal and suprahepatic veins). As a result of this, the blood brought from the digestive tract through the portal vein bypasses the liver, and the unmetabolized components of the portal bloodstream enter directly into systemic circulation, causing clinical symptoms of metabolic encephalopathy (HE). A 3-month-old Bichon canine patient with a history of seizures secondarily to a portosystemic shunt (PS), confirmed through color Doppler ultrasound exam and computed tomography, was presented for evaluation. The typical electroencephalographic (EEG) traces recorded were characterized by the presence of bilateral symmetrical triphasic waves, resembling non-convulsive status epilepticus. The presence of this EEG pattern is useful in choosing the best therapeutic option in order to not accentuate the HE sings and, consequently, to decrease the mortality risk due to a prolonged status epilepticus.

摘要

犬肝性脑病(HE)是一种中枢神经系统的代谢紊乱,继发于肝功能障碍,其病因可为后天性或先天性。门体分流是肝血管(门静脉和肝上静脉)之间存在异常交通。由此,经门静脉从消化道带回的血液绕过肝脏,门静脉血流中未代谢的成分直接进入体循环,导致代谢性脑病(HE)的临床症状。一只3个月大的比熊犬患者,有继发于门体分流(PS)的癫痫发作史,经彩色多普勒超声检查和计算机断层扫描确诊,前来接受评估。记录的典型脑电图(EEG)特征为双侧对称的三相波,类似非惊厥性癫痫持续状态。这种EEG模式的存在有助于选择最佳治疗方案,以避免加重HE症状,从而降低因长时间癫痫持续状态导致的死亡风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b61/11767108/fb61acfae536/life-15-00107-g001.jpg

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