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How Red Blood Cells Process Nitric Oxide: Evidence for the Nitrite Hypothesis.

作者信息

Gladwin Mark T

机构信息

From Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA; and Division of Pulmonary, Allergy and Critical Care Medicine, and Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA.

出版信息

Circulation. 2017 Jan 10;135(2):177-179. doi: 10.1161/CIRCULATIONAHA.116.024752.

DOI:10.1161/CIRCULATIONAHA.116.024752
PMID:28069711
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5385839/
Abstract
摘要

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Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation.脱氧血红蛋白将亚硝酸盐还原为一氧化氮，从而使人体循环血管舒张。
Nat Med. 2003 Dec;9(12):1498-505. doi: 10.1038/nm954. Epub 2003 Nov 2.
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Hemoglobin mediated nitrite activation of soluble guanylyl cyclase.血红蛋白介导的亚硝酸盐对可溶性鸟苷酸环化酶的激活作用。
Comp Biochem Physiol A Mol Integr Physiol. 2005 Oct;142(2):130-5. doi: 10.1016/j.cbpb.2005.04.016. Epub 2005 Jun 2.
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Am J Physiol Heart Circ Physiol. 2006 Nov;291(5):H2026-35. doi: 10.1152/ajpheart.00407.2006. Epub 2006 Jun 23.
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Oxid Med Cell Longev. 2017;2017:6201797. doi: 10.1155/2017/6201797. Epub 2017 Dec 12.
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The Hemoglobin Homolog Cytoglobin in Smooth Muscle Inhibits Apoptosis and Regulates Vascular Remodeling.平滑肌中的血红蛋白同源物细胞红蛋白可抑制细胞凋亡并调节血管重塑。
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本文引用的文献

1
Nitrite and S-Nitrosohemoglobin Exchange Across the Human Cerebral and Femoral Circulation: Relationship to Basal and Exercise Blood Flow Responses to Hypoxia.亚硝酸盐和 S-亚硝基血红蛋白在人体大脑和股循环中的交换：与基础和运动缺氧血流反应的关系。
Circulation. 2017 Jan 10;135(2):166-176. doi: 10.1161/CIRCULATIONAHA.116.024226. Epub 2016 Nov 15.
2
Globin X is a six-coordinate globin that reduces nitrite to nitric oxide in fish red blood cells.球蛋白X是一种六配位球蛋白，可在鱼类红细胞中将亚硝酸盐还原为一氧化氮。
Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):8538-43. doi: 10.1073/pnas.1522670113. Epub 2016 Jul 12.
3
Strategies to increase nitric oxide signalling in cardiovascular disease.增加心血管疾病中一氧化氮信号的策略。
Nat Rev Drug Discov. 2015 Sep;14(9):623-41. doi: 10.1038/nrd4623. Epub 2015 Aug 7.
4
Evidence mounts that red cells and deoxyhemoglobin can reduce nitrite to bioactive NO to mediate intravascular endocrine NO signaling: commentary on "Anti-platelet effects of dietary nitrate in healthy volunteers: involvement of cGMP and influence of sex".越来越多的证据表明，红细胞和脱氧血红蛋白可将亚硝酸盐还原为具有生物活性的一氧化氮，从而介导血管内内分泌一氧化氮信号传导：对“膳食硝酸盐对健康志愿者的抗血小板作用：环磷酸鸟苷的参与及性别影响”的评论
Free Radic Biol Med. 2013 Dec;65:1518-1520. doi: 10.1016/j.freeradbiomed.2013.09.020. Epub 2013 Oct 5.
5
Human neuroglobin functions as a redox-regulated nitrite reductase.人类神经红蛋白作为一种氧化还原调节的亚硝酸盐还原酶发挥作用。
J Biol Chem. 2011 May 20;286(20):18277-89. doi: 10.1074/jbc.M110.159541. Epub 2011 Feb 4.
6
Catalytic generation of N2O3 by the concerted nitrite reductase and anhydrase activity of hemoglobin.血红蛋白的亚硝酸盐还原酶和脱水酶协同活性催化生成三氧化二氮。
Nat Chem Biol. 2007 Dec;3(12):785-94. doi: 10.1038/nchembio.2007.46. Epub 2007 Nov 4.
7
Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration.脱氧肌红蛋白是一种亚硝酸盐还原酶，可生成一氧化氮并调节线粒体呼吸。
Circ Res. 2007 Mar 16;100(5):654-61. doi: 10.1161/01.RES.0000260171.52224.6b. Epub 2007 Feb 9.
8
Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis.铜蓝蛋白是一种决定内分泌一氧化氮稳态的一氧化氮氧化酶和亚硝酸盐合酶。
Nat Chem Biol. 2006 Sep;2(9):486-93. doi: 10.1038/nchembio813. Epub 2006 Aug 13.
9
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation.脱氧血红蛋白将亚硝酸盐还原为一氧化氮，从而使人体循环血管舒张。
Nat Med. 2003 Dec;9(12):1498-505. doi: 10.1038/nm954. Epub 2003 Nov 2.
10
Nitric oxide's reactions with hemoglobin: a view through the SNO-storm.一氧化氮与血红蛋白的反应：透过SNO风暴的视角
Nat Med. 2003 May;9(5):496-500. doi: 10.1038/nm0503-496.