胆囊切除患者中脱氧胆酸氧化还原增加。
Increased oxidoreduction of deoxycholic acid in cholecystectomised patients.
作者信息
Einarsson K, Nilsell K, Björkhem I
机构信息
Department of Medicine, Karolinska Institute, Huddinge University Hospital, Sweden.
出版信息
Gut. 1989 Sep;30(9):1275-8. doi: 10.1136/gut.30.9.1275.
The extent of oxidoreduction of deoxycholic acid in the enterohepatic circulation was studied in seven healthy subjects and seven patients after cholecystectomy. (12 beta-3H) Deoxycholic acid was given orally together with (24-14C) labelled bile acid. The rate of oxidoreduction of the 12 alpha-hydroxyl group of deoxycholic acid was calculated from the decay in ratio between 3H and 14C. In spite of a normal proportion of deoxycholic acid and other secondary bile acids in bile, patients after cholecystectomy had more than two-fold higher degree of oxidoreduction of the 12 alpha-hydroxyl group than healthy controls. The high extent of oxidoreduction is probably because of an increased exposure of the bile acid pool to intestinal bacteria and may have physiological implications.
在7名健康受试者和7名胆囊切除术后患者中研究了肠肝循环中脱氧胆酸的氧化还原程度。口服（12β-3H）脱氧胆酸和（24-14C）标记的胆汁酸。根据3H与14C比例的衰减计算脱氧胆酸12α-羟基的氧化还原速率。尽管胆汁中脱氧胆酸和其他次级胆汁酸的比例正常，但胆囊切除术后患者12α-羟基的氧化还原程度比健康对照组高两倍以上。氧化还原程度高可能是由于胆汁酸池与肠道细菌的接触增加，并且可能具有生理意义。
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