Jin Ping, Zhang Qin, Mo Zhaohui, Yang Fan, Xie Yanhong
Department of Endorcrinology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2016 Dec 28;41(12):1366-1370. doi: 10.11817/j.issn.1672-7347.2016.12.020.
Van Wyk-Grumbach syndrome (VWGS) is a rare complication of prolonged untreated juvenile hypothyroidism characterized by precocious puberty and enlarged multicystic ovaries. A 13-year-old girl visited our outpatient clinic due to menstrual irregularities. She had precocious puberty, pituitary hyperplasia and multiple cystic ovaries in addition to clinical signs of severe congenital hypothyroidism. After the initiation of L-thyroxine therapy, the symptoms were alleviated in a short time. This rare syndrome is easy to be misdiagnosed as pituitary and ovarian tumor. High degree of suspicion and timely diagnosis can prevent unnecessary surgical procedures because the symptoms can be reversed with thyroid hormone supplementation.
范·怀克-格伦巴赫综合征（VWGS）是长期未经治疗的青少年甲状腺功能减退症的一种罕见并发症，其特征为性早熟和多囊卵巢增大。一名13岁女孩因月经不调前来我院门诊就诊。除了严重先天性甲状腺功能减退症的临床体征外，她还患有性早熟、垂体增生和多囊卵巢。开始左旋甲状腺素治疗后，症状在短时间内得到缓解。这种罕见综合征容易被误诊为垂体和卵巢肿瘤。高度怀疑并及时诊断可避免不必要的手术，因为补充甲状腺激素可使症状逆转。
