Granberg S, Norén H, Friberg L G
Department of Oncology, University of Göteborg, Sahlgrenska sjukhuset, Sweden.
Gynecol Oncol. 1989 Nov;35(2):204-8. doi: 10.1016/0090-8258(89)90044-9.
Today, when all studies of treatment of ovarian cancer stages III and IV show disappointing long-term survival despite extensive surgery and chemotherapy, it is of interest to look a little further at the characteristics of early ovarian cancer to help the development of screening methods. For this purpose, stages I and II were analyzed during the periods 1969 to 1972 (group A, n = 172) and 1979 to 1982 (group B, n = 179). The total survival for stages I and II was 57% in group A and 66% in group B. In group A, survival was 74% for stage I and 41% for stage II; the corresponding data for group B were 68 and 65%. The difference between groups A and B for stage II is statistically significant. In stage I, survival was not found to be dependent on hysterectomy and bilateral salpingo-oophorectomy (SOEBH) or bilateral/unilateral salpingo-oophorectomy (SOEB/SOEU). In stage II, however, survival increased significantly after SOEBH. The best survival (80%, 28/35) occurred in group B, stage II, where high-voltage treatment was followed by melphalan for 6 months postoperatively.
如今，尽管对III期和IV期卵巢癌进行了广泛的手术和化疗，但所有相关治疗研究的长期生存率仍令人失望，因此进一步研究早期卵巢癌的特征以推动筛查方法的发展很有意义。为此，对1969年至1972年期间（A组，n = 172）和1979年至1982年期间（B组，n = 179）的I期和II期病例进行了分析。A组I期和II期的总生存率为57%，B组为66%。A组中，I期生存率为74%，II期为41%；B组的相应数据分别为68%和65%。A组和B组II期的差异具有统计学意义。在I期，未发现生存率取决于子宫切除术和双侧输卵管卵巢切除术（SOEBH）或双侧/单侧输卵管卵巢切除术（SOEB/SOEU）。然而，在II期，SOEBH后生存率显著提高。最佳生存率（80%，28/35）出现在B组II期，该组采用高压治疗，术后使用美法仑6个月。
