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细胞内感染期间的基因组分析数据。

Data on genome analysis of during intracellular infection.

作者信息

Matyushkina Daria, Pobeguts Olga, Garanina Irina, Babenko Vladislav, Vakhitova Maria, Fisunov Gleb, Govorun Vadim

机构信息

Laboratory of Proteomic Analysis, Federal Research and Clinical Centre of Physical-Chemical Medicine, Moscow 119435, Russia.

Laboratory of Proteomic Analysis, Federal Research and Clinical Centre of Physical-Chemical Medicine, Moscow 119435, Russia; Laboratory of Proteomics, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117997, Russia.

出版信息

Data Brief. 2016 Dec 8;10:264-268. doi: 10.1016/j.dib.2016.12.006. eCollection 2017 Feb.

Abstract

The genus relates to Gram-positive bacteria that lack a cell wall and are capable to cause chronic disease in humans and animals. Among the agents of infection and disease in domestic poultry and wild birds, is the most important mycoplasma species, causing considerable losses in the poultry industry. In the present paper, we provide data on adaptation of to the eukaryotic host cells on the genomic level. The major changes were predominantly localized in the VlhA-hemagglutinin genes which are important components of pathogenesis. The ability of mycoplasmas to change dramatically the repertoire of surface antigens and to vary the immunogenicity of these components allows them to remain undetected by the immune system of the host. The data presented in this article are related to the article entitled "Phase Transition of the Bacterium upon Invasion of a Host Cell as a Mechanism of Adaptation: a Model." (Matyushkina et al., 2016) [1]. Data posted in repository https://www.ncbi.nlm.nih.gov/bioproject/315515. Bioproject ID: PRJNA315515.

摘要

该属与缺乏细胞壁的革兰氏阳性细菌有关,能够在人类和动物中引发慢性疾病。在家禽和野鸟的感染及疾病病原体中,是最重要的支原体物种,给家禽业造成了相当大的损失。在本文中,我们提供了关于在基因组水平上适应真核宿主细胞的数据。主要变化主要集中在VlhA-血凝素基因上,这些基因是发病机制的重要组成部分。支原体能够极大地改变表面抗原库并改变这些成分的免疫原性,这使得它们能够不被宿主免疫系统察觉。本文所呈现的数据与题为《细菌侵入宿主细胞时的相变作为一种适应机制:模型》的文章相关。(Matyushkina等人,2016年)[1]。数据存于资料库https://www.ncbi.nlm.nih.gov/bioproject/315515。生物项目编号:PRJNA315515。

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