Kanti Varvara, Günther Malise, Stroux Andrea, Sawatzky Sabine, Henrich Wolfgang, Abou-Dakn Michael, Blume-Peytavi Ulrike, Garcia Bartels Natalie
Department of Dermatology and Allergy, Clinical Research Center for Hair and Skin Science, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Department of Medical Statistics and Clinical Epidemiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
J Cosmet Dermatol. 2017 Dec;16(4):500-507. doi: 10.1111/jocd.12302. Epub 2017 Jan 10.
Skin care influences skin barrier function during the first postnatal weeks. Although the use of natural oils in preterms has been investigated, there are currently no data comparing the effect of sunflower oil to an emollient on barrier development in healthy term newborns.
In a prospective, randomized clinical study, 50 healthy full-term newborns aged ≤72 h were randomly assigned to two groups: group baby lotion (L, n=22) and sunflower seed oil (SSO, n=24). The skin barrier function was evaluated in three anatomical areas (front, abdomen, and thigh) by noninvasive assessment of transepidermal water loss (TEWL), stratum corneum hydration (SCH), sebum, and skin pH at inclusion and after five weeks.
In both groups, skin pH decreased and SCH increased statistically significantly in all measured areas at W5 compared to baseline. TEWL decreased statistically significantly on the forearm in both groups, on the upper leg in group L, and on the abdomen in group SSO.
Both skin care regimes did not harm skin barrier function adaptation in healthy term neonates during the first five weeks of life.
在出生后的最初几周，皮肤护理会影响皮肤屏障功能。尽管已经对早产儿使用天然油脂进行了研究，但目前尚无数据比较葵花籽油与润肤剂对健康足月儿皮肤屏障发育的影响。
在一项前瞻性随机临床研究中，将50名年龄≤72小时的健康足月儿随机分为两组：婴儿润肤露组（L组，n = 22）和葵花籽油组（SSO组，n = 24）。在纳入研究时以及五周后，通过无创评估经表皮水分流失（TEWL）、角质层水合作用（SCH）、皮脂和皮肤pH值，对三个解剖部位（前额、腹部和大腿）的皮肤屏障功能进行评估。
与基线相比，在第5周时，两组所有测量部位的皮肤pH值均下降，SCH均显著升高。两组在前臂的TEWL均显著下降，L组在大腿上部，SSO组在腹部的TEWL也显著下降。
在生命的前五周，两种皮肤护理方案均未损害健康足月儿的皮肤屏障功能适应性。
