Garcia Bartels Natalie, Scheufele Ramona, Prosch Franziska, Schink Tania, Proquitté Hans, Wauer Roland R, Blume-Peytavi Ulrike
Department of Dermatology and Allergy, Clinical Research Center for Hair and Skin Science, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Pediatr Dermatol. 2010 Jan-Feb;27(1):1-8. doi: 10.1111/j.1525-1470.2009.01068.x.
The effect of topical skin care products on neonatal skin barrier during first 8 weeks of life has not been scientifically evaluated. In a prospective, randomized clinical study, we compared the influence of three skin care regimens to bathing with water on skin barrier function in newborns at four anatomic sites. A total of 64 healthy, full-term neonates (32 boys and 32 girls) aged <48 hours were randomly assigned to four groups receiving twice-weekly: WG, bathing with wash gel (n = 16); C, bathing and cream (n = 16); WG + C, bathing with wash gel plus cream (n = 16); and B, bathing with water (n = 16). Transepidermal water loss, stratum corneum hydration, skin pH, sebum were measured on day 2, week 2, 4, 8 of life on front, abdomen, upper leg, and buttock. Skin condition was scored and microbiologic colonization was documented. After 8 weeks, group WG + C showed significantly lower transepidermal water loss on front, abdomen, and upper leg as well as higher stratum corneum hydration on front and abdomen compared with group B. Similarly, group C showed lower transepidermal water loss and higher stratum corneum hydration on these body regions. Group WG revealed significantly lower pH on all sites compared with group B at week 8. No differences in sebum level, microbiologic colonization and skin condition score were found. Skin care regimens did not harm physiologic neonatal skin barrier adaptation within the first 8 weeks of life. However, significant influence of skin care on barrier function was found in a regional specific fashion.
局部皮肤护理产品对新生儿出生后前8周皮肤屏障的影响尚未得到科学评估。在一项前瞻性随机临床研究中，我们比较了三种皮肤护理方案与清水沐浴对新生儿四个解剖部位皮肤屏障功能的影响。共有64名年龄小于48小时的健康足月儿（32名男婴和32名女婴）被随机分为四组，每周接受两次护理：WG组，使用沐浴露沐浴（n = 16）；C组，沐浴并涂抹乳霜（n = 16）；WG + C组，使用沐浴露沐浴并涂抹乳霜（n = 16）；B组，清水沐浴（n = 16）。在出生后第2天、第2周、第4周和第8周，测量前额、腹部、大腿上部和臀部的经表皮水分流失、角质层水合作用、皮肤pH值和皮脂。对皮肤状况进行评分并记录微生物定植情况。8周后，与B组相比，WG + C组在前额、腹部和大腿上部的经表皮水分流失显著降低，前额和腹部的角质层水合作用更高。同样，C组在这些身体部位的经表皮水分流失较低，角质层水合作用较高。在第8周时，与B组相比，WG组所有部位的pH值显著降低。在皮脂水平、微生物定植和皮肤状况评分方面未发现差异。皮肤护理方案在新生儿出生后的前8周内不会损害生理性皮肤屏障适应。然而，发现皮肤护理对屏障功能有区域特异性的显著影响。
