Dubuc P U
Sansum Medical Research Foundation, Santa Barbara, California.
Horm Metab Res. 1989 Oct;21(10):546-9. doi: 10.1055/s-2007-1009284.
Many of the disturbances which characterize adult C57BL/6 ob/ob mice, including obesity, hypometabolism and hypothermia could arise from reduced circulating levels of thyrotropin and thyroid hormones. In the present study, measurement of these hormones in ad libitum-fed obese and lean mice housed at 22 degrees C revealed that mutant mice had levels of TSH equal to those of their ?/+ siblings, while total T4 and T3 concentrations were slightly higher than those of lean controls. The hormonal responses of obese mice to overnight food deprivation or to meal ingestion were also similar to those of lean control mice. Males of both phenotypes typically had higher TSH, T4 and T3 concentrations than did females, and in male mice the circulating levels of each hormone were much more responsive to the feeding condition. The present data are consistent with recent reports of defective target tissue responses and impaired hormone deiodination rather than depressed pituitary-thyroid hormone levels in accounting for the metabolic disturbances which characterize ob/ob mice.
许多表征成年C57BL/6 ob/ob小鼠的紊乱情况，包括肥胖、代谢减退和体温过低，可能源于促甲状腺激素和甲状腺激素循环水平的降低。在本研究中，对自由采食、饲养于22摄氏度环境下的肥胖和瘦小鼠的这些激素进行测量发现，突变小鼠的促甲状腺激素水平与其+/？同胞小鼠相当，而总甲状腺素和三碘甲状腺原氨酸浓度略高于瘦对照小鼠。肥胖小鼠对过夜禁食或进食的激素反应也与瘦对照小鼠相似。两种表型的雄性小鼠促甲状腺激素、甲状腺素和三碘甲状腺原氨酸浓度通常高于雌性小鼠，并且在雄性小鼠中，每种激素的循环水平对进食状况的反应更为敏感。目前的数据与最近关于靶组织反应缺陷和激素脱碘受损的报道一致，而非垂体 - 甲状腺激素水平降低导致了表征ob/ob小鼠的代谢紊乱。
