Mobley P W, Dubuc P U
Horm Metab Res. 1979 Jan;11(1):37-9. doi: 10.1055/s-0028-1092679.
Examination of the thyroid hormone levels of C57BL/6J ob/ob mice and their lean littermates between the ages of 6 days and 22 weeks revealed that obese mice have significantly reduced hormone concentrations between 10 and 21 days of age. Thereafter, the values remained equal to, or above those or their lean littermates. The present data indicate that the hypometabolism and abnormal thermal regulation of weanling mice could be a result of diminished thyroid hormone levels, but that other mechanisms must be responsible for the persistence of these abnormalities in adult ob/ob mice.
对6日龄至22周龄的C57BL/6J ob/ob小鼠及其瘦的同窝小鼠的甲状腺激素水平进行检测后发现，肥胖小鼠在10至21日龄时激素浓度显著降低。此后，其数值保持与瘦的同窝小鼠相等或高于后者。目前的数据表明，断奶小鼠的代谢减退和体温调节异常可能是甲状腺激素水平降低的结果，但其他机制必定是成年ob/ob小鼠这些异常持续存在的原因。
