Barranco S C, Flournoy D R, Bolton W E, Oka M S
J Natl Cancer Inst. 1978 Nov;61(5):1307-10. doi: 10.1093/jnci/61.5.1307.
The effects of the anticancer drug diglycolaldehyde (NSC-118994) were studied on Chinese hamster ovary cells growing in vitro. Dividing cells, specifically those in S-phase, were more sensitive to the drug than were nondividing cells, although a large fraction of nondividing cells was also killed by doses up to 800 microgram/ml. Dose-dependent effects on cell progression kinetics were observed in all phases of the cell cycle except in mitosis, during which treated cells progressed at control rates into G1-phase. The inhibition of cell progression from G1- into S-phase (most sensitive phase of the cell cycle) put self-limiting restrictions on the cell killing effects of the drug.
研究了抗癌药物二甘醇醛（NSC - 118994）对体外培养的中国仓鼠卵巢细胞的作用。正在分裂的细胞，特别是处于S期的细胞，比未分裂的细胞对该药物更敏感，尽管高达800微克/毫升的剂量也能杀死很大一部分未分裂的细胞。在细胞周期的所有阶段都观察到了对细胞进程动力学的剂量依赖性影响，但在有丝分裂期间除外，在此期间处理过的细胞以对照速率进入G1期。从G1期进入S期（细胞周期中最敏感的阶段）的细胞进程受到抑制，这对药物的细胞杀伤作用产生了自我限制。
