Morton and Gloria Shulman Movement Disorders Centre and Edmund J Saffra Program in Parkinson's Disease, Tornto Western Hospital, Toronto, Ontario, Canada.
The Parkinson's Institute and Clinical Center, Sunnyvale, California, USA.
Mov Disord. 2017 Apr;32(4):610-614. doi: 10.1002/mds.26896. Epub 2017 Jan 10.
Heart rate variability is reduced in idiopathic PD, indicating cardiac autonomic dysfunction likely resulting from peripheral autonomic synucleinopathy. Little is known about heart rate variability in leucine-rich repeat kinase 2-associated PD.
This study investigated heart rate variability in LRRK2-associated PD.
Resting electrocardiograms were obtained from 20 individuals with LRRK2-associated PD, 37 nonmanifesting carriers, 48 related noncarriers, 26 idiopathic PD patients, and 32 controls. Linear regression modelling compared time and frequency domain values, adjusting for age, sex, heart rate, and disease duration.
Low-frequency power and the ratio of low-high frequency power were reduced in idiopathic PD versus controls (P < .008, P < .029 respectively). In contrast, individuals with LRRK2-associated PD were not statistically different from controls in any parameter measured. Furthermore, all parameters trended toward being higher in LRRK2-associated PD when compared with idiopathic PD.
Heart rate variability may remain intact in LRRK2-associated PD, adding to a growing literature supporting clinical-pathologic differences between LRRK2-associated and idiopathic PD. © 2017 International Parkinson and Movement Disorder Society.
特发性帕金森病患者的心率变异性降低，表明心脏自主神经功能障碍可能是由于外周自主神经突触核蛋白病引起的。关于富亮氨酸重复激酶 2 相关帕金森病患者的心率变异性知之甚少。
本研究旨在探讨富亮氨酸重复激酶 2 相关帕金森病患者的心率变异性。
从 20 名富亮氨酸重复激酶 2 相关帕金森病患者、37 名非表现性携带者、48 名相关非携带者、26 名特发性帕金森病患者和 32 名对照者中获得静息心电图。通过线性回归模型比较时间和频域值，调整年龄、性别、心率和疾病持续时间。
与对照组相比，特发性帕金森病患者的低频功率和低高频功率比降低（P < .008，P < .029）。相比之下，LRRK2 相关帕金森病患者在任何测量参数上均与对照组无统计学差异。此外，与特发性帕金森病相比，LRRK2 相关帕金森病患者的所有参数均呈升高趋势。
LRRK2 相关帕金森病患者的心率变异性可能保持完整，这增加了越来越多的支持 LRRK2 相关帕金森病和特发性帕金森病之间临床病理差异的文献。
