Shaw H M, McCarthy S W, McCarthy W H, Thompson J F, Milton G W
Department of Surgery, University of Sydney, Australia.
Histopathology. 1989 Sep;15(3):257-65. doi: 10.1111/j.1365-2559.1989.tb03076.x.
We attempted to clarify the prevailing controversy regarding the significance of regression in thin (less than 0.76 mm) primary melanomas. Of 7540 patients with cutaneous melanomas treated at the Sydney Melanoma Unit, 28 first presented with a thin primary lesion and concurrent regional lymph node metastases (stage II). Major differences in tumour histology existed between these patients and stage I patients with thin lesions that subsequently recurred. Regression was present in all 28 lesions in stage II patients. In 61 stage I patients ultimately developing a recurrence, 67% of lesions displayed regression. Significantly, however, in 735 stage I patients ultimately not developing a recurrence, 61% of lesions also displayed regression. Why regression occurs so frequently in thin lesions which never recur is unclear. Our results suggest that the histology of thin primary melanomas may be influenced by the presence or absence of metastases in patients at that time.
我们试图澄清关于薄型（小于0.76毫米）原发性黑色素瘤中消退现象的重要性这一普遍存在的争议。在悉尼黑色素瘤中心接受治疗的7540例皮肤黑色素瘤患者中，有28例首次出现薄型原发性病变并伴有区域淋巴结转移（II期）。这些患者与随后复发的I期薄型病变患者在肿瘤组织学上存在重大差异。II期患者的所有28个病变均出现消退。在最终复发的61例I期患者中，67%的病变显示有消退。然而，值得注意的是，在最终未复发的735例I期患者中，61%的病变也显示有消退。薄型病变中从未复发的情况下消退为何如此频繁发生尚不清楚。我们的结果表明，薄型原发性黑色素瘤的组织学可能受当时患者有无转移的影响。
