Roses D F, Harris M N, Hidalgo D, Valensi Q J, Dubin N
Arch Surg. 1982 Jul;117(7):921-3. doi: 10.1001/archsurg.1982.01380310035008.
We studied 119 patients with stage I primary cutaneous malignant melanoma, who were undergoing regional lymph node dissection, to determine the relationship of lymph node metastases to thickness of the primary lesion. The lymph nodes in the dissection specimen were each evaluated by serial sections. None of the patients with lesions less than 1.0 mm thick had nodal micrometastases. When lesions exceeded 1.0 mm in thickness, there was no appreciable increase in the incidence of nodal metastases until a thickness greater than 4.0 mm was reached, in which cases the incidence of metastases was 50%. Predictive variables were determined by multiple logistic regression analysis. Only lesions that were at least 4.0 mm thick and were not located on the upper extremities were significant predictors of lymph node metastases; within this category there was a 64% incidence of lymph node metastases.
我们研究了119例I期原发性皮肤恶性黑色素瘤患者，这些患者正在接受区域淋巴结清扫术，以确定淋巴结转移与原发灶厚度之间的关系。对清扫标本中的淋巴结逐一进行连续切片评估。原发灶厚度小于1.0 mm的患者均无淋巴结微转移。当病灶厚度超过1.0 mm时，在厚度达到大于4.0 mm之前，淋巴结转移发生率没有明显增加，在这些病例中转移发生率为50%。通过多元逻辑回归分析确定预测变量。只有厚度至少为4.0 mm且不在上肢的病灶是淋巴结转移的显著预测因素；在这一类别中，淋巴结转移发生率为64%。
