手性有机催化的 3-亚烷基氧化吲哚与烯醛的反式 vinylogous Michael 反应。
Enantioselective Organocatalyzed Vinylogous Michael Reactions of 3-Alkylidene Oxindoles with Enals.
机构信息
State Key Laboratory of Elemento-Organic Chemistry, Department of Chemistry, Nankai University , Tianjin 300071, People's Republic of China.
Collaborative Innovation Center of Chemical Science and Engineering, Nankai University , Tianjin 300071, People's Republic of China.
出版信息
J Org Chem. 2017 Feb 3;82(3):1412-1419. doi: 10.1021/acs.joc.6b02582. Epub 2017 Jan 19.
An efficient asymmetric vinylogous Michael addition of 3-alkylidene oxindoles and enals has been achieved using a chiral TBS-protected diphenylprolinol catalyst. The γ-substituted alkylidene oxindoles obtained bear a chiral tertiary center and are afforded in moderate to good yields and good to excellent enantioselectivities.
一种高效的不对称乙烯基迈克尔加成反应，用于 3-亚烷基氧化吲哚和烯醛的反应，使用手性 TBS 保护的二苯脯氨醇催化剂实现。得到的γ-取代亚烷基氧化吲哚具有手性叔中心，产率中等至良好，对映选择性优异。
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