Jiang Z D, Zhao G, Lu G R
Centre for Biomedical Engineering, Department of Electronic Science and Technology, University of Science and Technology of China, Hefei, CHina.
Centre for Biomedical Engineering, Department of Electronic Science and Technology, University of Science and Technology of China, Hefei; Anhui Provincial Engineering Technology Research Center for Biopreservation and Artificial Organs, Hefei, China.
Cryo Letters. 2016 Nov/Dec;37(6):427-431.
BACKGROUND: Cryotherapy and hyperthermia are effective treatments for several diseases, especially for liver cancers. Thermal conductivity is a significant thermal property for the prediction and guidance of surgical procedure. However, the thermal conductivities of organs and tissues, especially over the temperature range of both cryotherapy and hyperthermia are scarce.
To provide comprehensive thermal conductivity of liver for both cryotherapy and hyperthermia.
A hot probe made of stain steel needle and micron-sized copper wire is used for measurement. To verify data processing, both the least square method and the Monte Carlo inversion method are used to determine the hot probe constants, respectively, with reference materials of water and 29.9 % CaCl aqueous solution. Then the thermal conductivities of Hanks solution and pork liver bathed in Hanks solution are measured.
The effective length for two methods is nearly the same, but the heat capacity of probe calibrated by the Monte Carlo inversion is temperature dependent. Fairly comprehensive thermal conductivity of porcine liver measured with these two methods in the target temperature range is verified to be similar.
We provide an integrated thermal conductivity of liver for cryotherapy and hyperthermia in two methods, and make more accurate predictions possible for surgery. The least square method and the Monte Carlo inversion method have their advantages and disadvantages. The least square method is available for measurement of liquids that not prone to convection or solids in a wide temperature range, while the Monte Carlo inversion method is available for accurate and rapid measurement.
背景：冷冻疗法和热疗是治疗多种疾病的有效方法，尤其是肝癌。热导率是预测和指导手术过程的重要热学性质。然而，器官和组织的热导率，特别是在冷冻疗法和热疗的温度范围内的数据却很稀少。
提供肝脏在冷冻疗法和热疗中的综合热导率。
使用由不锈钢针和微米级铜线制成的热探针进行测量。为了验证数据处理，分别使用最小二乘法和蒙特卡罗反演法，以水和29.9%氯化钙水溶液作为参考材料来确定热探针常数。然后测量汉克斯溶液以及浸泡在汉克斯溶液中的猪肝的热导率。
两种方法的有效长度几乎相同，但通过蒙特卡罗反演校准的探针热容量与温度有关。经验证，在目标温度范围内用这两种方法测量的猪肝综合热导率相似。
我们通过两种方法提供了肝脏在冷冻疗法和热疗中的综合热导率，使手术预测更准确。最小二乘法和蒙特卡罗反演法各有优缺点。最小二乘法适用于测量不易对流的液体或在较宽温度范围内的固体，而蒙特卡罗反演法适用于准确快速测量。
