Delannoy J, Giaux G, Dittmar A, Newman W H, Delhomme G, Delvalee D
Oscar Lambret Cancer Center, Lille, France.
Int J Hyperthermia. 1990 Jan-Feb;6(1):143-54. doi: 10.3109/02656739009140811.
Temperature and effective thermal conductivity (including the convective effects due to tissue blood flow) profiles have been mapped both within a perfused phantom model containing a differentially perfused pseudo-tumour and in patients undergoing microwave (915 MHz) hyperthermia. These measurements demonstrate the influence of differential thermal characteristics of tumour vs. normal tissue on the temperature distributions obtained during hyperthermia. Effective thermal conductivity was measured using a self-heated thermistor probe, and temperature profiles were measured by means of conventional thermocouples and fibre-optic temperature probes. Measurements of effective thermal conductivity obtained in patients prior to microwave hyperthermia, and temperature profiles obtained once steady-state treatment conditions had been attained, show a strong relation between the effective thermal conductivity profile and the ability to obtain therapeutic temperatures without excessive heating of intervening tissues. These observations were confirmed in phantom experiments, demonstrating that this perfused phantom is a more realistic physical model than the conventional unperfused gels usually employed as physical models for hyperthermia experiments. These results demonstrate that tissue thermal clearance is an important determinant of treatment temperature fields, independent of and in addition to the SAR distribution of the particular applicator. Effective thermal conductivity measurements of the different tissues constituting the volume to be heated could be an important index in the planning and optimization of treatment strategies.
温度和有效热导率（包括由于组织血流引起的对流效应）分布已在包含差异灌注假肿瘤的灌注体模模型内以及接受微波（915MHz）热疗的患者体内进行了测绘。这些测量结果证明了肿瘤与正常组织的差异热特性对热疗期间获得的温度分布的影响。使用自热热敏电阻探头测量有效热导率，并通过传统热电偶和光纤温度探头测量温度分布。在微波热疗前患者中获得的有效热导率测量结果，以及在达到稳态治疗条件后获得的温度分布，显示出有效热导率分布与在不过度加热中间组织的情况下获得治疗温度的能力之间存在密切关系。这些观察结果在体模实验中得到了证实，表明这种灌注体模是比通常用作热疗实验物理模型的传统未灌注凝胶更现实的物理模型。这些结果表明，组织热清除是治疗温度场的一个重要决定因素，独立于特定 applicator 的 SAR 分布且除此之外。构成待加热体积的不同组织的有效热导率测量可能是治疗策略规划和优化中的一个重要指标。
