Papadakis Georgios Z, Millo Corina, Sadowski Samira M, Karantanas Apostolos H, Bagci Ulas, Patronas Nicholas J
From the *Radiology and Imaging Sciences, Warren Grant Magnuson Clinical Center, †PET Department; Clinical Center, and ‡Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD; §Endocrine and Thoracic Surgery, University Hospitals of Geneva, Geneva, Switzerland; ∥Department of Radiology, Medical School, University of Crete, Greece; and ¶Center for Research in Computer Vision, Electrical and Computer Science Department, University of Central Florida, Orlando, FL.
Clin Nucl Med. 2017 Mar;42(3):209-210. doi: 10.1097/RLU.0000000000001527.
Fibrous dysplasia of the bone is a developmental benign skeletal disorder characterized by replacement of normal bone and normal bone marrow with abnormal fibro-osseous tissue. We report on a case of a biopsy-proven fibrous dysplasia lesion in the left temporal bone, with intensely increased activity (SUVmax, 56.7) on Ga-DOTATATE PET/CT. The presented data indicate cell surface overexpression of somatostatin receptors by fibrous dysplastic cells and highlight the need of cautious management of Ga-DOTATATE-avid bone lesions, which could mimic malignancy especially in patients with history of neuroendocrine tumors.
骨纤维异常增殖症是一种发育性良性骨骼疾病，其特征是正常骨和正常骨髓被异常纤维-骨组织所取代。我们报告一例经活检证实的左侧颞骨纤维异常增殖症病变，在镓[68Ga] DOTATATE PET/CT上有强烈的活性增加（SUVmax，56.7）。所呈现的数据表明纤维异常增殖细胞表面生长抑素受体过表达，并强调需要谨慎处理镓[68Ga] DOTATATE摄取阳性的骨病变，尤其是在有神经内分泌肿瘤病史的患者中，这些病变可能酷似恶性肿瘤。
