Zhang W, Xu G X, Li J J, Liu X, Chen Y J, Zhang F
Department of Pathology, Wannan Medical College Yijishan Hospital, Wuhu 241001, China.
Zhonghua Bing Li Xue Za Zhi. 2017 Jan 8;46(1):20-24. doi: 10.3760/cma.j.issn.0529-5807.2017.01.005.
To investigate the correlation between the expression of PD-1, PD-L1 and clinicopathologic parameters in triple negative breast carcinoma (TNBC). Samples from 151 patients with TNBC and 65 cases of other breast carcinomas (non-TNBC) were examined for PD-L1 and PD-1 expression by immunohistochemical staining on tissue microarray. The expression of PD-L1 and PD-1 in the tumor cells and interstitial lymphocytes in TNBC was significantly (<0.05)higher than that in non-TNBC.In TNBC, the expression rates of PD-L1 in the cancer nests and stroma were 16.6%(25/151) and 25.2%(38/151)respectively.The former was positively correlated with tumor histological grade and lymph node metastasis (<0.05), and the latter only with tumor histological grade (<0.05). The expression rate of PD-1 was 27.2% (41/151), and correlated with PD-L1 expression in stromal tumor-infiltrating lymphocytes (<0.05). The expression of PD-L1 in TNBC is significantly correlated with high-grade histology, lymph node metastasis and PD-L1 expression in stromal tumor-infiltrating lymphocytes.
探讨三阴性乳腺癌（TNBC）中PD-1、PD-L1表达与临床病理参数之间的相关性。通过组织芯片免疫组化染色检测151例TNBC患者及65例其他乳腺癌（非TNBC）患者样本中PD-L1和PD-1的表达情况。TNBC肿瘤细胞和间质淋巴细胞中PD-L1和PD-1的表达显著（<0.05）高于非TNBC。在TNBC中，癌巢和间质中PD-L1的表达率分别为16.6%（25/151）和25.2%（38/151）。前者与肿瘤组织学分级和淋巴结转移呈正相关（<0.05），后者仅与肿瘤组织学分级相关（<0.05）。PD-1的表达率为27.2%（41/151），与间质肿瘤浸润淋巴细胞中PD-L1的表达相关（<0.05）。TNBC中PD-L1的表达与高级别组织学、淋巴结转移及间质肿瘤浸润淋巴细胞中PD-L1的表达显著相关。
