高 PD-L1 表达与肿瘤浸润淋巴细胞密切相关，并导致中国三阴性乳腺癌患者的良好临床结局。

High PD-L1 Expression Is Closely Associated With Tumor-Infiltrating Lymphocytes and Leads to Good Clinical Outcomes in Chinese Triple Negative Breast Cancer Patients.

机构信息

Breast Disease Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.

Department of Breast and Thyroid Surgery, The Seventh Affiliated Hospital, Sun Yat-sen University, ShenZhen, 518107, China.

出版信息

Int J Biol Sci. 2017 Sep 5;13(9):1172-1179. doi: 10.7150/ijbs.20868. eCollection 2017.

BACKGROUND

To investigate the role of Programmed death ligand 1 (PD-L1) expression and tumor-infiltrating lymphocytes (TILs) in tumor recurrence and metastasis of Chinese patients suffering from triple negative breast cancer (TNBC).

METHODS

PD-L1 immunohistochemistry was performed on 215 TNBCs. Also, the prevalence of TILs correlated the expression of PD-L1 and TILs with clinical outcomes. Kaplan-Meier and the model analyses of univariate Cox proportional hazards were utilized to compare the survival of patients with positive PD-L1 expression with those with negative PD-L1 expression.

RESULTS

The median follow-up time was 67.7 months (range: 7-159 months). PD-L1-positive breast cancer patients had significantly longer disease-free survival (DFS) and Overall survival (OS) compared with PD-L1-negative patients (P=0.046; P=0.019) in TNBC. The presence of increased stromal lymphocytic infiltrates (STILs) was significantly associated with overall survival (P=0.026). The model analysis of univariate Cox proportional hazards showed that PD-L1 and STILs were independent prognostic factors for tumor prognosis.

CONCLUSIONS

Our study found that high levels of PD-L1 could be expressed in TNBC, which was correlated with the prevalence of TILs.

背景

为了研究程序性死亡配体 1（PD-L1）表达和肿瘤浸润淋巴细胞（TILs）在中国人患有三阴性乳腺癌（TNBC）肿瘤复发和转移中的作用。

方法

对 215 例 TNBC 进行 PD-L1 免疫组化染色。同时，TILs 的流行率与 PD-L1 和 TILs 的表达与临床结局相关。采用 Kaplan-Meier 和单因素 Cox 比例风险模型分析比较 PD-L1 阳性表达和阴性表达的患者的生存情况。

结果

中位随访时间为 67.7 个月（范围：7-159 个月）。与 PD-L1 阴性患者相比，PD-L1 阳性乳腺癌患者在 TNBC 中具有显著更长的无病生存期（DFS）和总生存期（OS）（P=0.046；P=0.019）。间质淋巴细胞浸润（STILs）的存在与总生存期显著相关（P=0.026）。单因素 Cox 比例风险模型分析显示，PD-L1 和 STILs 是肿瘤预后的独立预后因素。