[FoxM1与乳腺癌耐药蛋白在非特殊类型浸润性乳腺癌中的表达及其预后意义]

[Expression of FoxM1 and BCRP in invasive breast carcinoma of no special type and its prognosis significance].

作者信息

Liu Y, Liu Y P, Liu J Y, Yang H C, Wang Z D

机构信息

Department of Pathology, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.

出版信息

Zhonghua Bing Li Xue Za Zhi. 2017 Jan 8;46(1):30-33. doi: 10.3760/cma.j.issn.0529-5807.2017.01.007.

DOI:10.3760/cma.j.issn.0529-5807.2017.01.007

PMID:28072973

Abstract

To investigate the relationship between expression of FoxM1 and BCRP in invasive breast carcinoma of no special type (IBC-NST) tissues and the clinical pathological characteristics and prognosis of the patients. Seventy-eight cases of IBC-NST with excision were included. The expression of FoxM1 and BCRP was assessed by immunohistochemistry and its relationship with the clinical pathological characteristics and prognosis was evaluated. FoxM1 was expressed in 71.8%(56/78) of IBC-NST, and the expression was related to tumor diameter, TNM staging, ER, PR and HER2. BCRP was expressed in 53.8% (42/78) of IBC-NST, and the expression was related to age, tumor diameter, lymph node metastasis, ER and HER2. Kaplan-Meier survival analysis showed the survival time was related to tumor diameter, TNM staging, lymph node metastasis and the expression of FoxM1, BCRP, ER, PR and HER2. Cox multivariate analysis showed that TNM staging, FoxM1, BCRP, HER2 were determinants of patient survival time. The expression of FoxM1 is associated with tumor diameter, TNM staging, ER, PR and HER2 while BCRP is associated with age, tumor diameter, lymph node metastasis, ER and HER2. Both FoxM1 and BCRP have prognostic significance in IBC-NST patients.

摘要

探讨非特殊类型浸润性乳腺癌（IBC-NST）组织中FoxM1和BCRP的表达与患者临床病理特征及预后的关系。纳入78例接受手术切除的IBC-NST患者。采用免疫组织化学法评估FoxM1和BCRP的表达，并评估其与临床病理特征及预后的关系。FoxM1在71.8%（56/78）的IBC-NST中表达，其表达与肿瘤直径、TNM分期、雌激素受体（ER）、孕激素受体（PR）和人表皮生长因子受体2（HER2）有关。BCRP在53.8%（42/78）的IBC-NST中表达，其表达与年龄、肿瘤直径、淋巴结转移、ER和HER2有关。Kaplan-Meier生存分析显示，生存时间与肿瘤直径、TNM分期、淋巴结转移以及FoxM1、BCRP、ER、PR和HER2的表达有关。Cox多因素分析显示，TNM分期、FoxM1、BCRP、HER2是患者生存时间的决定因素。FoxM1的表达与肿瘤直径、TNM分期、ER、PR和HER2有关，而BCRP的表达与年龄、肿瘤直径、淋巴结转移、ER和HER2有关。FoxM1和BCRP在IBC-NST患者中均具有预后意义。