安抚不安的胃：肠癌细胞的神经调控

Settling a Nervous Stomach: The Neural Regulation of Enteric Cancer.

机构信息

Department of Neurology, Stanford University, Stanford, CA 94305, USA.

出版信息

Cancer Cell. 2017 Jan 9;31(1):1-2. doi: 10.1016/j.ccell.2016.12.008.

DOI:10.1016/j.ccell.2016.12.008

Abstract

The nervous system is emerging as a regulator of malignancy. In this issue of Cancer Cell, Hayakawa et al. demonstrate a feedforward signaling loop in which tumor-derived nerve growth factor promotes enteric tumor innervation, and recruited nerves drive cancer growth through acetylcholine-regulated Wnt signaling and stimulation of further NGF release.

摘要

神经系统正成为恶性肿瘤的调控者。在本期《癌细胞》杂志中，Hayakawa 等人展示了一个前馈信号环路，其中肿瘤衍生的神经生长因子促进肠源性肿瘤神经支配，募集的神经通过乙酰胆碱调节的 Wnt 信号和进一步的 NGF 释放来驱动癌症生长。