Budzynska Barbara, Michalak Agnieszka, Frankowska Małgorzata, Kaszubska Katarzyna, Biała Grażyna
Medical University of Lublin, Department of Pharmacology and Pharmacodynamics, Lublin, Poland.
Medical University of Lublin, Department of Pharmacology and Pharmacodynamics, Lublin, Poland.
Pharmacol Rep. 2017 Apr;69(2):199-205. doi: 10.1016/j.pharep.2016.10.006. Epub 2016 Oct 11.
Abuse of more than one psychoactive drug is becoming a global problem. Our experiments were designed to examine the effects of a concomitant administration of 3,4-methylenedioxy-methamphetamine (MDMA) and mephedrone on depression- and anxiety-like behaviors and cognitive processes in Swiss mice.
In order to investigate the drug interactions the forced swimming test (FST) - an animal model of depression, the passive avoidance (PA) test - a memory and learning paradigm, as well as the elevated plus maze (EPM) test - test for anxiety level were used.
The results revealed that a concomitant administration of non-effective doses of mephedrone (1mg/kg) and MDMA (1mg/kg) exerted marked antidepressive effects in the FST. Also a co-administration of mephedrone (2.5mg/kg) and MDMA (1mg/kg) displayed a pro-cognitive action in the PA paradigm. Furthermore, even though mephedrone and MDMA can, in general, exert some anxiogenic effects in mice, the concomitant administration of nonactive doses of both drugs (0.05 and 0.1mg/kg, respectively) in the EPM test, did not show any synergistic effect in our study.
The effects of mephedrone and MDMA combination on mammalian organisms were attempted to be evaluated in our study and the results are described in the present report. These results may help explain the reasons for and consequences of a concomitant administration of psychoactive substances with regards to the central nervous system, while being possibly useful in the treatment of polydrug intoxication.
滥用多种精神活性药物正成为一个全球性问题。我们的实验旨在研究3,4-亚甲基二氧甲基苯丙胺（摇头丸）和甲麻黄碱联合给药对瑞士小鼠抑郁样和焦虑样行为以及认知过程的影响。
为了研究药物相互作用，使用了强迫游泳试验（FST）——一种抑郁动物模型、被动回避（PA）试验——一种记忆和学习范式，以及高架十字迷宫（EPM）试验——焦虑水平测试。
结果显示，非有效剂量的甲麻黄碱（1mg/kg）和摇头丸（1mg/kg）联合给药在FST中产生了显著的抗抑郁作用。甲麻黄碱（2.5mg/kg）和摇头丸（1mg/kg）联合给药在PA范式中也表现出促认知作用。此外，尽管甲麻黄碱和摇头丸一般会在小鼠中产生一些致焦虑作用，但在EPM试验中，两种药物的非活性剂量（分别为0.05和0.1mg/kg）联合给药在我们的研究中未显示出任何协同作用。
我们的研究试图评估甲麻黄碱和摇头丸联合使用对哺乳动物机体的影响，本报告中描述了相关结果。这些结果可能有助于解释精神活性物质联合给药在中枢神经系统方面的原因和后果，同时可能对治疗多药中毒有用。
