摇头丸与大脑：关于神经递质在神经毒性中作用的简短综述
MDMA and the Brain: A Short Review on the Role of Neurotransmitters in Neurotoxicity.
作者信息
Mustafa Nor Suliana, Bakar Nor Hidayah Abu, Mohamad Nasir, Adnan Liyana Hazwani Mohd, Fauzi Nurul Farah Aina Md, Thoarlim Abdulsoma, Omar Syed Hadzrullathfi Syed, Hamzah Mohd Shafiee, Yusoff Zawawi, Jufri Mahdi, Ahmad Rashidi
机构信息
Centre for Research in Addiction (CentRenA), University of Sultan Zainal Abidin, Terengganu, Malaysia.
Faculty of Medicine, City Campus, University of Sultan Zainal Abidin, Terengganu, Malaysia.
出版信息
Basic Clin Neurosci. 2020 Jul-Aug;11(4):381-388. doi: 10.32598/bcn.9.10.485. Epub 2020 Jul 1.
N-Methyl-3, 4-methylenedioxyamphetamine (MDMA), or ecstasy is a recreational drug of abuse. It is a synthetic substance that affects the body's systems, which its mechanism of action and treatment should be more investigated. MDMA provides an immediate enjoyable feeling by stimulating the release of neurotransmitters, such as dopamine and serotonin in the brain. Unfortunately, abnormal regulation of the brain neurotransmitters, as well as the increased oxidative stress causes damage to the brain neurons after the MDMA exposure. Only a few studies have been done regarding its treatment. Thus, the treatment of MDMA complications should be further explored mainly by targeting its mechanism of action in the neurotransmitter systems. Hence, this study presents a short review regarding the recent findings on the role of neurotransmitters to cause MDMA neurotoxicity. The results will be useful for future research in elucidating the potential treatment based on the targeted mechanisms to treat the neurotoxic effects of MDMA.
N-甲基-3,4-亚甲基二氧基苯丙胺（MDMA），即摇头丸，是一种滥用的娱乐性药物。它是一种影响人体系统的合成物质，其作用机制和治疗方法仍需进一步研究。MDMA通过刺激大脑中多巴胺和血清素等神经递质的释放，立即产生愉悦感。不幸的是，MDMA暴露后，大脑神经递质的异常调节以及氧化应激增加会导致脑神经元受损。关于其治疗的研究很少。因此，MDMA并发症的治疗应主要通过针对其在神经递质系统中的作用机制进行进一步探索。因此，本研究简要回顾了神经递质在导致MDMA神经毒性方面的最新研究结果。这些结果将有助于未来基于靶向机制治疗MDMA神经毒性的潜在治疗方法的研究。
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