Kumar K P, Krishnaswami S, Prasad N K, Rath P C, Jose J
Indian Heart J. 1989 Jul-Aug;41(4):240-4.
A study of the effects of low dose Metoprolol was undertaken in 37 patients with acute myocardial infarction. These patients were randomly divided into three groups depending on the dose of the drug per kg body weight. Group I, consisting of 18 patients, received 0.36 to 0.65 mg per kg per day, Group II (10 patients) received 0.66 to 0.99 mg/kg/day, and Group III (9 patients) 1 to 1.81 mg/kg/day. To assess the degree of beta blockade achieved, the parameters that were evaluated were the fall in blood pressure and heart rate. There was a fall in systolic blood pressure which ranged from 7 to 17%, and fall in heart rate of 6.6 to 12.8% in the 3 groups over the 48-hour study period. These observations were compared with the results obtained from the Goteberg Metoprolol trial and Metoprolol in acute myocardial infarction (MIAMI) trials wherein 200 mg of Metoprolol per day were used. Our preliminary observations suggest that Indian patients may not need such a high dose, and Metoprolol at 50-100 mg per day would probably be sufficient to get the desired effect.
对37例急性心肌梗死患者进行了低剂量美托洛尔疗效的研究。根据每千克体重的药物剂量，这些患者被随机分为三组。第一组由18名患者组成，每天每千克体重接受0.36至0.65毫克的美托洛尔；第二组（10名患者）每天每千克体重接受0.66至0.99毫克；第三组（9名患者）每天每千克体重接受1至1.81毫克。为了评估所达到的β受体阻滞程度，所评估的参数是血压和心率的下降情况。在48小时的研究期间，三组患者的收缩压下降幅度为7%至17%，心率下降幅度为6.6%至12.8%。这些观察结果与在哥德堡美托洛尔试验和急性心肌梗死美托洛尔试验（MIAMI试验）中获得的结果进行了比较，后者每天使用200毫克美托洛尔。我们的初步观察结果表明，印度患者可能不需要如此高的剂量，每天50至100毫克的美托洛尔可能足以达到预期效果。
