St. Mark's Hospital & Academic Institute, Harrow, London HA1 3UJ, UK.
Surgical Epidemiology, Trials and Outcome Centre (SETOC), St. Mark's Hospital & Academic Institute, Harrow, London HA1 3UJ, UK.
Can J Gastroenterol Hepatol. 2016;2016:8723949. doi: 10.1155/2016/8723949. Epub 2016 Dec 15.
. Previous epidemiological studies suggest a higher rate of pancolonic disease in South Asians (SA) compared with White Europeans (WE). The aim of the study was to compare colectomy rates for ulcerative colitis (UC) in SA to those of WE. . Patients with UC were identified from a national administrative dataset (Hospital Episode Statistics, HES) between 1997 and 2012 according to ICD-10 diagnosis code K51 for UC. The colectomy rate for each ethnic group was calculated as the proportion of patients who underwent colectomy from the total UC cases for that group. . Of 212,430 UC cases, 73,318 (35.3%) were coded for ethnicity. There was no significant difference in the colectomy rate between SA and WE (6.93% versus 6.90%). Indians had a significantly higher colectomy rate than WE (9.8% versus 6.9%, < 0.001). Indian patients were 21% more likely to require colectomy for UC compared with WE group (OR: 1.21, 95% CI: 1.04-1.42, and = 0.001). . Given the limitations in coding, the colectomy rate in this cohort was higher in Indians compared to WE. A prospectively recruited ethnic cohort study will decipher whether this reflects a more aggressive phenotype or is due to other confounding factors.
先前的流行病学研究表明，南亚人（SA）的全结肠炎发病率高于白种欧洲人（WE）。本研究旨在比较 SA 和 WE 中溃疡性结肠炎（UC）的结肠切除术率。
根据 ICD-10 诊断代码 K51，1997 年至 2012 年间，通过国家行政数据集（医院入院统计，HES）确定 UC 患者。每个种族群体的结肠切除术率计算为该群体中接受结肠切除术的患者比例。
在 212430 例 UC 病例中，73318 例（35.3%）编码为种族。SA 和 WE 之间的结肠切除术率没有显著差异（6.93%比 6.90%）。印度人结肠切除术率明显高于 WE（9.8%比 6.9%，<0.001）。与 WE 组相比，印度患者因 UC 接受结肠切除术的可能性高 21%（OR：1.21，95%CI：1.04-1.42，P=0.001）。
鉴于编码存在局限性，与 WE 相比，该队列中印度人的结肠切除术率较高。一项前瞻性招募的种族队列研究将阐明这是否反映了更具侵袭性的表型，还是由于其他混杂因素所致。
