Department of Radiology, Cumming School of Medicine, McCaig Institute for Bone and Joint Health, University of Calgary, 3280 Hospital Drive NW, Calgary, Alberta, T2N 4Z6, Canada.
CaMos Centre Director, Departments of Medicine, Community Health Sciences, and Oncology, McCaig Institute of Bone and Joint Health, University of Calgary, 3280 Hospital Drive NW, Calgary, Alberta, T2N 4Z6, Canada.
Osteoporos Int. 2017 Apr;28(4):1423-1431. doi: 10.1007/s00198-016-3900-4. Epub 2017 Jan 10.
The rate of change in bone density was not different between peri- and post-menopausal women. Differences in rate of change were observed in bone microarchitecture, specifically cortical porosity (Ct.Po), where peri-menopausal women increased +9% per year compared with the +6% per year for post-menopausal women.
The purpose of this study was to compare changes in bone density and microarchitecture in peri- and post-menopausal women over 6 years.
Peri- (n = 26) and post- (n = 65) menopausal women were selected from the Canadian Multicenter Osteoporosis Study. Caucasian women were scanned on dual x-ray absorptiometry (DXA) and high-resolution peripheral quantitative computed tomography (HR-pQCT) at baseline and follow-up, an average 6 years later. To compare repeat scans, automated 3D image registration was conducted. At the radius and tibia, total volumetric BMD (Tt.BMD), total bone area (Tt.Ar) and cortical porosity (Ct.Po) were assessed, and finite element analysis estimated apparent bone strength.
At the tibia, the rate of change for Ct.Po and Tt.Ar was different between groups. Peri-menopausal women had a + 9% per year increase in Ct.Po, but this increase was slower for post-menopausal women at +6% per year (p = 0.049). In addition, post-menopausal women had an increase in Tt.Ar of +0.13% per year compared with a slower increase of +0.06% per year for peri-menopausal women (p = 0.017). The rate of change of density between groups was not significantly different and was approximately -1% per year at the hip by DXA, and -1% per year at the radius and -0.5% per year tibia by HR-pQCT.
This is a 6-year prospective HR-pQCT study exploring rate of change in Caucasian peri- and post-menopausal women. The microarchitectural features represented by Ct.Po and Tt.Ar changed at a significantly different rate between groups, but group differences were not detected by density measures.
绝经前后女性的骨密度变化率无差异。骨微观结构的变化率存在差异，特别是皮质孔隙率（Ct.Po），绝经前女性每年增加 9%，而绝经后女性每年增加 6%。
本研究旨在比较绝经前后女性 6 年内骨密度和微观结构的变化。
从加拿大多中心骨质疏松症研究中选择绝经前（n=26）和绝经后（n=65）女性。白人女性在基线和随访时（平均 6 年后）接受双能 X 线吸收法（DXA）和高分辨率外周定量计算机断层扫描（HR-pQCT）扫描。为了比较重复扫描，进行了自动 3D 图像配准。在桡骨和胫骨处，评估了总容积骨密度（Tt.BMD）、总骨面积（Tt.Ar）和皮质孔隙率（Ct.Po），并通过有限元分析估计了表观骨强度。
在胫骨处，Ct.Po 和 Tt.Ar 的变化率在组间存在差异。绝经前女性的 Ct.Po 每年增加 9%，但绝经后女性的增加速度较慢，为每年 6%（p=0.049）。此外，绝经后女性的 Tt.Ar 每年增加 0.13%，而绝经前女性的增加速度较慢，为每年 0.06%（p=0.017）。组间密度变化率无显著差异，DXA 测量的髋部约为每年-1%，HR-pQCT 测量的桡骨和胫骨分别为每年-1%和-0.5%。
这是一项为期 6 年的前瞻性 HR-pQCT 研究，探讨了白种人绝经前后女性的变化率。Ct.Po 和 Tt.Ar 等微观结构特征的变化率在组间存在显著差异，但密度测量未检测到组间差异。
